Prostium E 0.06% Gel (Estradiol)
Price range: $92.10 through $197.60Required
| Pack Size | Price | Unit Price | Quantity | |
|---|---|---|---|---|
| 2 Tube | $92.10 | $46.05 / tube | ||
| 4 Tube | $147.90 | $36.98 / tube | ||
| 6 Tube | $197.60 | $32.93 / tube |
About Prostium E 0.06% Gel (Estradiol)
Medicine information
- Active ingredient
- Estradiol
- Indication
- Hormone replacement therapy (HRT) for estrogen-deficiency symptoms associated with menopause. Indian regulatory information for 17β-estradiol gel 0.06% w/w also includes prevention of osteoporosis in postmenopausal women at high risk of future fractures when other approved osteoporosis medicines are unsuitable.
- Strength
- 0.06 %
- Dosage form
- Gel
- Route
- Transdermal
Medicine overview
Prostium E 0.06% Gel contains estradiol, an estrogen hormone used as hormone replacement therapy for symptoms caused by reduced estrogen after menopause. Estradiol is chemically and biologically similar to the main estrogen produced by the ovaries before menopause. The gel is applied to the skin, allowing estradiol to pass through the skin and enter the bloodstream. Indian regulatory information identifies 17β-estradiol gel 0.06% w/w as an HRT formulation for postmenopausal estrogen-deficiency symptoms.
What it is used for
Estradiol 0.06% gel is used for hormone replacement therapy in postmenopausal women with symptoms related to estrogen deficiency, including vasomotor symptoms such as hot flushes. Indian regulatory information for this formulation also includes prevention of postmenopausal osteoporosis in women at high fracture risk who cannot use, or have contraindications to, other approved osteoporosis treatments.
How it works
Estradiol replaces some of the estrogen that the body produces in lower amounts after menopause. It binds to estrogen receptors and produces effects similar to naturally occurring estrogen in estrogen-responsive tissues. Restoring estrogen activity can reduce menopausal symptoms associated with estrogen deficiency. Estradiol delivered through a transdermal gel is absorbed across the skin into the systemic circulation rather than being taken by mouth.
How it is taken
Apply the gel to the skin exactly as directed by the prescriber and the product-specific package instructions. Estradiol 0.06% gel is for skin use and should not be applied to the breasts or in or around the vagina. For the referenced metered-pump 0.06% estradiol formulation, the gel is spread in a thin layer over the arm from wrist to shoulder, allowed to dry, and hands are washed with soap and water afterward. Avoid skin contact between other people and the application area for at least 1 hour. Do not assume that another estradiol gel's pump quantity is interchangeable with Prostium E unless the Prostium E package instructions confirm it.
Important warnings
Do not use systemic estradiol gel in patients with undiagnosed abnormal genital bleeding, known or suspected estrogen-dependent cancer, active or previous deep-vein thrombosis or pulmonary embolism, active or previous arterial thromboembolic disease such as stroke or myocardial infarction, significant liver disease, known thrombophilic disorders, or serious hypersensitivity to the product where these contraindications apply. Unopposed systemic estrogen increases endometrial cancer risk in women with a uterus; a prescriber should assess whether a progestogen is required. Estrogen therapy is also associated with important risks including thromboembolic and cardiovascular events and certain malignancies. Seek prompt medical assessment for unusual vaginal bleeding, symptoms suggesting a blood clot or stroke, sudden vision changes, or a severe allergic reaction. CYP3A4 inhibitors or inducers may alter estrogen exposure. The gel contains alcohol and may be flammable until dry; keep it away from flames and smoking during this period.
Side effects and monitoring
Common effects reported with systemic estradiol gel include headache, breast pain or tenderness, nausea and vomiting; application-site reactions may also occur. Less common but clinically important risks of systemic estrogen include venous thromboembolism, stroke, cardiovascular events, gallbladder disease and estrogen-dependent malignancies. Unexpected or persistent vaginal bleeding requires medical assessment. Patients using systemic menopausal hormone therapy should be reviewed periodically so that ongoing need, benefits and risks can be reassessed.
Pregnancy
Estradiol gel used for menopausal hormone therapy is not indicated during pregnancy. If pregnancy occurs or is suspected, contact the prescriber for advice.
Breastfeeding
Estrogens are present in human milk and may reduce breast-milk production. The need for estradiol treatment and the benefits of breastfeeding should be considered together with potential effects on the breastfed child and milk supply.
Food, drink and interactions
No specific interaction between drinking alcohol and Prostium E 0.06% Gel was verified. The gel formulation itself contains alcohol and is flammable until dry, so avoid smoking, fire and open flames during application and until the treated skin has dried.
Food and drink
No specific food or drink restrictions were verified for transdermal estradiol 0.06% gel.
Frequently asked questions
Where should I apply estradiol gel?
Follow the application area specified in the Prostium E package instructions. For the referenced 0.06% estradiol metered-pump formulation, the gel is spread thinly over the arm from wrist to shoulder; do not apply it to the breasts or in or around the vagina.
Do I need to rub estradiol gel completely into my skin?
No. The referenced 0.06% estradiol gel instructions say to spread it in a thin layer and allow it to dry rather than massage or rub it in.
Can someone else touch my skin after I apply estradiol gel?
Avoid contact between other people and the application site for at least 1 hour with the referenced 0.06% estradiol gel formulation. Wash your hands with soap and water after applying it to reduce accidental transfer.
What should I do if my menopause symptoms return while using the gel?
Contact the prescriber for review rather than changing the amount yourself. Menopausal hormone therapy should be reassessed periodically for effectiveness, ongoing need and safety.
Does estradiol gel increase the risk of blood clots?
Systemic estrogen therapy is associated with thromboembolic risks, including deep-vein thrombosis and pulmonary embolism. Estradiol gel should not be used in patients with active or previous DVT or pulmonary embolism where the prescribing contraindications apply.
Do I need progesterone with estradiol gel?
Women with a uterus who use systemic estrogen generally need their clinician to consider a progestogen because unopposed estrogen increases the risk of endometrial cancer. The appropriate regimen must be determined by the prescriber.
Can I smoke immediately after applying Prostium E Gel?
Keep away from smoking, flames and fire until the gel is completely dry. Alcohol-containing estradiol gels are flammable before drying.
Can Cheap Generic Med ship Prostium E Gel internationally?
Cheap Generic Med serves multiple international destinations, but product-specific shipping availability for Prostium E Gel is NOT VERIFIED. Prescription and personal-import requirements can also vary by destination.
Sources
Medical information notice: This information does not replace advice from a qualified healthcare professional. Use prescription medicine only as directed by the prescriber and the approved product information.
| Packaging | Qty |
|---|---|
| Delivery Time | 6 To 15 days |
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