Ferium 1K Injection 20 ml (Ferric Carboxymaltose)
Price range: $864.40 through $2,458.00Required
| Pack Size | Price | Unit Price | Quantity | |
|---|---|---|---|---|
| 3 Injection | $864.40 | $288.13 / injection | ||
| 6 Injection | $1,665.40 | $277.57 / injection | ||
| 9 Injection | $2,458.00 | $273.11 / injection |
About Ferium 1K Injection 20 ml (Ferric Carboxymaltose)
Medicine information
- Active ingredient
- Ferric carboxymaltose
- Indication
- Treatment of iron deficiency when oral iron preparations are ineffective or cannot be used, including iron deficiency anaemia. Ferric carboxymaltose 50 mg/mL is approved in India for iron deficiency in adults in these circumstances, with an additional approved indication for children and adolescents older than 1 year when oral iron is ineffective or cannot be used.
- Manufacturer
- Emcure Pharmaceuticals Ltd.
- Packaging
- 1 × 20 mL vial containing 1,000 mg elemental iron as ferric carboxymaltose (50 mg/mL).
- Strength
- 1000 mg
- Dosage form
- Injection
- Route
- Intravenous
Medicine overview
Ferium 1K Injection 20 mL is an intravenous iron replacement medicine containing ferric carboxymaltose. Each mL provides ferric carboxymaltose equivalent to 50 mg of elemental iron, giving 1,000 mg in the 20 mL vial. It is used to replenish iron when oral iron treatment is ineffective or cannot be used. The medicine delivers iron directly into the bloodstream, where it becomes available for haemoglobin production and restoration of the body's iron stores.
What it is used for
Ferium 1K is used for treatment of iron deficiency when oral iron preparations are ineffective or cannot be used. Ferric carboxymaltose is an established treatment for iron deficiency anaemia, including patients who cannot tolerate or do not respond adequately to oral iron. Indian regulatory records also include use in children and adolescents older than 1 year when oral iron preparations are ineffective or cannot be used.
How it works
Ferric carboxymaltose is a complex containing iron bound to a carbohydrate called carboxymaltose. After intravenous administration, the complex releases iron that can be taken up and used by the body. The supplied iron helps replenish depleted iron stores and provides iron needed to make haemoglobin, the protein in red blood cells responsible for carrying oxygen.
How it is taken
Ferium 1K is given intravenously by a healthcare professional; it is not taken by mouth. Ferric carboxymaltose may be administered as a slow intravenous injection or infusion according to the prescribed regimen and product instructions. For the 1,000 mg/20 mL strength, authoritative ferric carboxymaltose prescribing information permits a 1,000 mg dose to be given as a slow intravenous push over 15 minutes; when given by infusion, up to 1,000 mg may be diluted in sterile 0.9% sodium chloride and infused over at least 15 minutes. The actual dose is determined clinically and should not be self-administered.
Important warnings
Do not use ferric carboxymaltose in patients with known hypersensitivity to ferric carboxymaltose or its components. Serious hypersensitivity reactions, including potentially fatal anaphylactic-type reactions, can occur, so treatment must be given where emergency treatment is immediately available and the patient can be observed during administration and for at least 30 minutes afterward. Ferric carboxymaltose can cause severe or prolonged hypophosphataemia (low blood phosphate), occasionally resulting in osteomalacia or fractures; risk is greater with factors such as vitamin D deficiency, malnutrition, inflammatory bowel disease, malabsorption and hyperparathyroidism, although cases can occur without recognized risk factors. Pre-existing hypophosphataemia should be corrected, and serum phosphate should be checked when clinically indicated, particularly with repeat treatment. Blood pressure can rise temporarily after administration. Extravasation—medicine leaking outside the vein—may cause long-lasting brown skin discoloration.
Side effects and monitoring
Common adverse effects reported with intravenous ferric carboxymaltose include nausea, temporary increases in blood pressure, flushing, injection-site reactions, skin redness, dizziness and hypophosphataemia. Headache, vomiting, altered taste and injection-site discoloration can also occur. Serious or less common problems include severe hypersensitivity or anaphylactic-type reactions, marked hypophosphataemia, hypotension, fainting, breathing difficulty and angioedema. Seek urgent medical attention for difficulty breathing, swelling, collapse, severe dizziness or other signs of a serious allergic reaction. Patients should be monitored during and for at least 30 minutes after administration. Blood pressure should be monitored, and phosphate monitoring is particularly important in patients at risk of persistent low phosphate or receiving repeat courses.
Pregnancy
Ferric carboxymaltose should be used during pregnancy only after clinical assessment of the benefits and potential risks. Available human data are insufficient to establish the risk of major birth defects or miscarriage. Severe maternal hypersensitivity reactions to intravenous iron can have serious fetal consequences, including fetal bradycardia. Untreated iron deficiency anaemia during pregnancy also carries maternal and fetal risks.
Breastfeeding
Ferric carboxymaltose-derived iron can be present in breast milk. Available evidence has not identified serious adverse reactions attributable to exposure through breast milk, although constipation and diarrhoea have been reported among breastfed infants in available studies. The mother's clinical need for treatment and the benefits of breastfeeding should be considered together with any potential effects on the infant.
Food and drink
No food-related administration requirement was identified in the authoritative prescribing information because ferric carboxymaltose is administered intravenously rather than absorbed through the gastrointestinal tract. Patients should follow any additional instructions given by the healthcare professional administering the infusion.
Storage
Store in a cool, dark place at 8°C to 25°C. Keep out of reach of children. Product-specific Indian ferric carboxymaltose labelling also states not to refrigerate.
Frequently asked questions
Why do I need an iron infusion instead of iron tablets?
Ferric carboxymaltose may be used when oral iron cannot be used, is not tolerated, or has not produced an adequate response. Your healthcare professional determines whether intravenous iron is appropriate.
How quickly is Ferium 1K given?
The 1,000 mg ferric carboxymaltose strength can be administered intravenously over at least 15 minutes under appropriate clinical supervision, depending on the prescribed method of administration.
Why do I need to stay for observation after the infusion?
Serious allergic reactions can occur during or after ferric carboxymaltose administration. Patients should be observed for signs of hypersensitivity during treatment and for at least 30 minutes afterward, until clinically stable.
Can ferric carboxymaltose cause low phosphate levels?
Yes. Ferric carboxymaltose can cause hypophosphataemia, and severe or prolonged cases have occasionally caused bone problems and fractures. Phosphate monitoring is particularly important for patients with risk factors or those receiving repeat treatment.
Can the injection leave a brown mark on my skin?
Yes, if ferric carboxymaltose leaks from the vein into surrounding tissue, it can cause long-lasting brown discoloration. Tell the healthcare professional immediately if you notice pain, swelling or leakage around the injection site.
What symptoms after an iron infusion need urgent medical attention?
Difficulty breathing, swelling, fainting, collapse, severe dizziness or other symptoms of a serious allergic reaction require immediate medical attention. Severe persistent fatigue, muscle weakness or pain, bone or joint pain may also warrant evaluation for low phosphate.
Can Ferium 1K be used during pregnancy?
It may be considered when a clinician determines that treatment is needed, but pregnancy requires individual benefit-risk assessment. Severe hypersensitivity reactions to intravenous iron can have serious consequences for the fetus.
Do I need a prescription for Ferium 1K?
Yes. Ferium 1K is a prescription medicine in India and should be administered under medical supervision.
Sources
Medical information notice: This information does not replace advice from a qualified healthcare professional. Use prescription medicine only as directed by the prescriber and the approved product information.
| Active Ingredients | Ferric Carboxymaltose |
|---|---|
| Manufacturer | Emcure Pharmaceuticals |
| Packaging | Qty |
| strength | 50mg |
| Delivery Time | 6 To 15 days |
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