Zoldron 4 Mg Injection (Zoledronic Acid)
Price range: $209.21 through $517.84Required
| Pack Size | Price | Unit Price | Quantity | |
|---|---|---|---|---|
| 2 Injection | $209.21 | $104.61 / injection | ||
| 4 Injection | $375.14 | $93.79 / injection | ||
| 6 Injection | $517.84 | $86.31 / injection |
About Zoldron 4 Mg Injection (Zoledronic Acid)
Medicine information
- Active ingredient
- Zoledronic acid
- Delivery time
- United States, United Kingdom, Canada, Australia: typically 10–14 business days after dispatch; Europe: typically 12–18 business days; Middle East and other served destinations: typically 14–21 business days. These are estimates and customs or local carrier delays may extend delivery. Cheap_Generic_Med_Shipping_Coun…
- Indication
- Treatment of hypercalcemia of malignancy; treatment of bone lesions associated with multiple myeloma and bone metastases from solid tumors, together with standard antineoplastic therapy.
- Manufacturer
- Getwell Pharma India Private Limited (Getwell Pharmaceuticals)
- Packaging
- Combipack containing one 5 mL vial with zoledronic acid equivalent to 4 mg anhydrous zoledronic acid and one 5 mL ampoule of Sterile Water for Injection IP for reconstitution.
- Strength
- 4 mg
- Dosage form
- Sterile lyophilized powder for injection with sterile water for injection diluent
- Route
- Intravenous infusion
Medicine overview
Zoldron 4 mg is an intravenous bisphosphonate medicine containing zoledronic acid. It is supplied as a sterile lyophilized powder that must be reconstituted and diluted before intravenous infusion. Zoldron is used in cancer care to treat high blood calcium caused by malignancy and to manage bone lesions associated with multiple myeloma or solid tumors that have spread to bone. Zoledronic acid reduces the excessive breakdown of bone caused by osteoclasts, the cells responsible for bone resorption.
What it is used for
Zoldron 4 mg is indicated for hypercalcemia of malignancy, meaning an abnormally high blood calcium level caused by cancer. It is also used with standard cancer treatment for bone lesions associated with multiple myeloma and for bone metastases from solid tumors. The exact treatment plan depends on the indication, kidney function, laboratory results, and the patient's overall cancer treatment.
How it works
Zoledronic acid is a nitrogen-containing bisphosphonate that inhibits osteoclast-mediated bone resorption. Osteoclasts normally break down old bone, but their activity can become excessive in some cancers. By reducing this bone breakdown, zoledronic acid decreases the release of calcium from bone and helps limit skeletal damage associated with multiple myeloma and bone metastases. Its strong affinity for mineralized bone allows the medicine to act primarily at sites of active bone remodeling.
How it is taken
Zoldron is administered by intravenous infusion by a healthcare professional; it is not given as a direct injection. The vial is reconstituted with the supplied 5 mL Sterile Water for Injection IP, and the resulting solution is then diluted in 100 mL of a compatible calcium-free infusion solution. The infusion must run for at least 15 minutes. Patients should be adequately hydrated before treatment when appropriate, and serum creatinine should be checked before each dose. Treatment frequency and any renal dose adjustment depend on the indication and kidney function.
Important warnings
Do not use Zoldron in patients with hypersensitivity to zoledronic acid or its formulation components. Zoledronic acid can cause clinically important kidney toxicity; kidney function should be assessed before treatment, and severe renal impairment requires particular caution. Correct dehydration before treatment where appropriate and monitor calcium, phosphate, magnesium, and other relevant electrolytes. Hypocalcemia can occur and should be corrected before treatment when present. Osteonecrosis of the jaw has been reported, particularly in cancer patients receiving intravenous bisphosphonates, so a dental examination and appropriate preventive dental care should be considered before therapy; invasive dental procedures during treatment require medical and dental assessment. Serious musculoskeletal pain, atypical femoral fractures, severe hypersensitivity reactions, and bronchoconstriction in aspirin-sensitive patients have also been reported. Zoldron should not be used concurrently with another zoledronic-acid product. Avoid mixing the infusion with calcium-containing or other divalent-cation-containing solutions.
Side effects and monitoring
Common effects associated with zoledronic acid include nausea, fatigue, anemia, bone pain, constipation, fever, vomiting, and shortness of breath. An acute-phase reaction may occur after an infusion, particularly early in treatment, with fever, chills, headache, and muscle, bone, or joint aches. Serious effects include kidney impairment, hypocalcemia, osteonecrosis of the jaw, severe musculoskeletal pain, serious allergic reactions, and atypical femoral fractures. Seek prompt medical attention for facial or throat swelling, breathing difficulty, severe or persistent jaw pain, unusual thigh or groin pain, muscle spasms or tingling suggestive of low calcium, or substantially reduced urination. Serum creatinine should be checked before each treatment, with appropriate monitoring of calcium and other electrolytes.
Pregnancy
Zoledronic acid can cause fetal harm and should not be administered during pregnancy. Pregnancy status should be verified before treatment in patients who could become pregnant, and effective contraception is advised during and after treatment. Because zoledronic acid binds to bone and may be released for an extended period, patients planning a future pregnancy should discuss this with their healthcare professional.
Breastfeeding
Breastfeeding is not recommended during and after zoledronic acid treatment because it is unknown whether zoledronic acid is present in human milk, and serious adverse effects in a breastfed child are possible. Zoledronic acid remains bound to bone for prolonged periods.
Food and drink
No specific food restriction is established for this intravenous medicine; patients may generally continue their normal diet unless their healthcare professional advises otherwise. Adequate hydration is important around treatment when clinically appropriate. Calcium and vitamin D supplementation may be prescribed for patients receiving treatment for multiple myeloma or bone metastases.
Storage
Store Zoldron below 25°C and protect it from light. Follow the product instructions for handling after reconstitution and dilution.
Frequently asked questions
What should I expect after my first Zoldron infusion?
Some people develop an acute-phase reaction during the first few days after zoledronic acid, with fever, chills, headache, tiredness, or muscle, joint, and bone aches. Contact your healthcare team if symptoms are severe, persistent, or otherwise concerning.
Why does my dentist need to know that I receive zoledronic acid?
Zoledronic acid is associated with osteonecrosis of the jaw, a rare but serious problem involving damaged jawbone. Dental assessment before treatment and coordination between the dentist and treating clinician are particularly important if an extraction, implant, or other invasive dental procedure is being considered.
Do I need to drink extra water before a Zoldron infusion?
Adequate hydration is important, particularly when zoledronic acid is being used for hypercalcemia of malignancy. Your healthcare team should determine the appropriate fluid intake because some medical conditions can make excessive hydration unsuitable.
Why are kidney tests needed before Zoldron?
Zoledronic acid can affect kidney function. Serum creatinine should be assessed before treatment, and the dose or treatment plan may need adjustment or interruption when renal function is impaired.
Can Zoldron cause low calcium?
Yes. Zoledronic acid can cause hypocalcemia, or low blood calcium. Calcium and other relevant electrolytes may require monitoring, and calcium plus vitamin D supplementation is recommended in certain patients receiving treatment for multiple myeloma or bone metastases.
How long does a Zoldron infusion take?
The intravenous infusion must be given over at least 15 minutes. Zoldron requires reconstitution and dilution before administration and should be given by a healthcare professional.
Can I have a tooth extracted while receiving Zoldron?
Tell both your treating clinician and dentist before any invasive dental procedure. Tooth extraction and other procedures involving the jaw require careful assessment because intravenous bisphosphonates are associated with osteonecrosis of the jaw.
Can Cheap Generic Med ship Zoldron to the United States?
Cheap Generic Med serves the United States under its international shipping model, with delivery typically estimated at 10–14 business days after dispatch. This is not a guaranteed arrival time; customs, prescription, import, and local carrier requirements may affect an order.
Will my Zoldron shipment have tracking?
Under Cheap Generic Med's standard tracked international fulfilment model, a tracking number should be provided after dispatch. Carrier systems may take about 24–72 hours to begin showing movement.
Sources
Medical information notice: This information does not replace advice from a qualified healthcare professional. Use prescription medicine only as directed by the prescriber and the approved product information.
| Active Ingredients | Zoledronic acid (4Mg) |
|---|---|
| Manufacturer | Get Well Pharmaceutical Pvt Ltd |
| Packaging | Qty |
| strength | 4mg |
| Delivery Time | 6 To 15 days |
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