Zolenic 4 Mg Injection (Zoledronic Acid)
Price range: $135.31 through $333.30Required
| Pack Size | Price | Unit Price | Quantity | |
|---|---|---|---|---|
| 2 Injection | $135.31 | $67.66 / injection | ||
| 4 Injection | $235.57 | $58.89 / injection | ||
| 6 Injection | $333.30 | $55.55 / injection |
About Zolenic 4 Mg Injection (Zoledronic Acid)
Medicine information
- Active ingredient
- Zoledronic acid
- Indication
- Treatment of hypercalcemia of malignancy and prevention/treatment of skeletal complications in patients with multiple myeloma or documented bone metastases from solid tumors, together with standard anticancer treatment.
- Strength
- 4 mg
- Dosage form
- Injection
- Route
- Intravenous infusion
Medicine overview
Zolenic 4 Mg Injection contains zoledronic acid, a bisphosphonate medicine that acts on bone. The 4 mg strength of zoledronic acid injection is used mainly in cancer-related conditions, including high blood calcium caused by malignancy and bone complications associated with multiple myeloma or solid tumors that have spread to bone. It is administered by intravenous infusion under healthcare supervision rather than being self-injected. Kidney function, calcium levels, hydration status, and dental health require consideration during treatment.
What it is used for
Zoledronic acid 4 mg injection is used to treat hypercalcemia of malignancy, meaning an abnormally high blood calcium level caused by cancer. It is also used with standard anticancer therapy in patients with multiple myeloma or documented bone metastases from solid tumors to reduce skeletal complications such as pathological fractures, spinal cord compression, and the need for radiation or surgery to bone.
How it works
Zoledronic acid belongs to the bisphosphonate group of medicines. It binds strongly to mineralized bone and inhibits osteoclasts, the cells responsible for breaking down bone tissue. This reduces excessive bone resorption and limits the release of calcium from bone into the bloodstream. In cancer involving bone, slowing this process can help control malignancy-related high calcium levels and reduce complications caused by weakened or damaged bone.
How it is taken
Zoledronic acid 4 mg is administered into a vein by a trained healthcare professional. For the 4 mg/5 mL concentrate formulation, the required amount must be diluted before intravenous infusion and must not be given as a direct injection. The infusion should run for at least 15 minutes. Kidney function should be assessed before treatment, and adequate hydration is important. The exact dose and treatment interval depend on the indication and renal function and must be determined by the treating clinician.
Important warnings
Do not use zoledronic acid in patients with known hypersensitivity to the medicine or its components. It can cause clinically significant kidney injury, including renal failure; renal function should therefore be checked before treatment and monitored as appropriate. Hypocalcemia can occur and should be corrected before therapy. Osteonecrosis of the jaw has been reported, particularly in patients receiving treatment for cancer, so a dental assessment and appropriate preventive dental care should be considered before therapy. Avoid invasive dental procedures when possible during treatment. Severe bone, joint, or muscle pain and atypical femoral fractures have also been reported. Use caution with nephrotoxic medicines, aminoglycosides, loop diuretics, and other treatments that may lower calcium. Zoledronic acid products containing the same active ingredient should not be given concurrently.
Side effects and monitoring
Common adverse effects include nausea, fatigue, fever, vomiting, constipation, bone pain, anemia, and shortness of breath. Flu-like reactions such as fever, chills, muscle pain, or joint pain may occur after an infusion. Important serious effects include kidney impairment or renal failure, hypocalcemia, severe hypersensitivity reactions, osteonecrosis of the jaw, and atypical femoral fractures. Seek medical attention for facial or throat swelling, difficulty breathing, muscle spasms or tingling suggesting low calcium, reduced urination, persistent jaw pain or poor healing in the mouth, or new unexplained thigh or groin pain. Serum creatinine should be assessed before doses used for cancer-related indications, with calcium and other relevant electrolytes monitored as clinically appropriate.
Pregnancy
Zoledronic acid can cause fetal harm and should not be administered during pregnancy. Pregnancy status should be verified before starting treatment in females of reproductive potential, and effective contraception is advised during and after treatment because zoledronic acid can remain bound to bone for a prolonged period.
Breastfeeding
Breastfeeding is not recommended during and after treatment with zoledronic acid. It is not known whether zoledronic acid passes into human milk, and its prolonged retention in bone creates a potential risk of serious adverse effects in a breastfed child.
Food and drink
Zoledronic acid is given intravenously, so food does not determine its absorption. Adequate hydration is important, particularly around treatment, but excessive hydration should be avoided in patients in whom fluid overload may be a concern.
Frequently asked questions
Why do I need blood tests before a zoledronic acid infusion?
Kidney function and blood calcium need to be checked because zoledronic acid can affect the kidneys and may lower calcium levels. Monitoring helps the healthcare team determine whether treatment can be given safely.
Why is dental work important before zoledronic acid treatment?
Zoledronic acid has been associated with osteonecrosis of the jaw, a rare but serious problem involving damaged jawbone. A dental examination and preventive dental care are generally recommended before starting treatment, particularly for patients receiving it for cancer-related conditions.
Can I feel unwell after a zoledronic acid infusion?
Yes. Fever, chills, fatigue, and muscle, joint, or bone pain can occur after an infusion. Contact your healthcare team if symptoms are severe, persistent, or accompanied by other concerning symptoms.
How long does a zoledronic acid infusion take?
The 4 mg cancer-related formulation should be infused over no less than 15 minutes. It must be administered by a healthcare professional rather than injected directly by the patient.
Why is hydration important before zoledronic acid?
Adequate hydration can help reduce the risk of kidney complications, particularly when zoledronic acid is being used for malignancy-related high calcium. Patients at risk of fluid overload need individualized fluid management by their healthcare team.
Can zoledronic acid lower my calcium level too much?
Yes. Hypocalcemia can occur and may sometimes be serious. Tell your healthcare team promptly about muscle spasms, cramps, numbness, or tingling, and follow any prescribed calcium and vitamin D supplementation instructions.
Can I have a tooth extraction while receiving zoledronic acid?
Invasive dental procedures may increase concern about osteonecrosis of the jaw. Tell both your dentist and the clinician managing your zoledronic acid treatment before having an extraction or other invasive dental procedure.
Will I get tracking for a Cheap Generic Med order?
Under the standard fulfilment model, tracked international shipping is used and a tracking number should be provided after dispatch. Carrier systems may take 24–72 hours to begin showing movement.
Is Zolenic 4 Mg Injection a prescription medicine?
Yes. Zoledronic acid injection is a prescription treatment administered under healthcare supervision; prescription and documentation requirements can also vary by destination country.
Sources
Medical information notice: This information does not replace advice from a qualified healthcare professional. Use prescription medicine only as directed by the prescriber and the approved product information.
| Active Ingredients | Zoledronic acid (4Mg) |
|---|---|
| Manufacturer | Cytogen Pharmaceuticals India Pvt Ltd |
| Packaging | Qty |
| strength | 4mg |
| Delivery Time | 6 To 15 days |
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