Xolnic 4 Mg Injection (Zoledronic Acid)
Price range: $117.89 through $283.13Required
| Pack Size | Price | Unit Price | Quantity | |
|---|---|---|---|---|
| 3 Injection | $117.89 | $39.30 / injection | ||
| 6 Injection | $201.56 | $33.59 / injection | ||
| 9 Injection | $283.13 | $31.46 / injection |
About Xolnic 4 Mg Injection (Zoledronic Acid)
Medicine information
- Active ingredient
- Zoledronic acid
- Indication
- Treatment of hypercalcaemia of malignancy (high blood calcium caused by cancer) and prevention of skeletal complications in adults with multiple myeloma or bone metastases from solid tumours, when used with appropriate anticancer treatment.
- Manufacturer
- Khandelwal Laboratories Ltd
- Packaging
- 1 vial
- Strength
- 4 mg
- Dosage form
- Powder for injection
- Route
- Intravenous infusion
Medicine overview
Xolnic 4 Mg Injection contains zoledronic acid, a bisphosphonate medicine that reduces excessive breakdown of bone. Indian regulatory pricing data identify Xolnic 4 mg as a Khandelwal Laboratories product, while India’s National List of Essential Medicines lists zoledronic acid 4 mg as a powder for injection. Zoledronic acid 4 mg is used mainly in cancer-related bone disease, including high blood calcium caused by cancer and prevention of skeletal complications associated with multiple myeloma or solid tumours that have spread to bone. It is administered by intravenous infusion.
What it is used for
Zoledronic acid 4 mg is used to treat hypercalcaemia of malignancy, where cancer causes an abnormally high calcium level in the blood. It is also used with standard anticancer therapy to reduce skeletal complications in adults with multiple myeloma and documented bone metastases from solid tumours. These complications can include pathological fractures and other bone-related events.
How it works
Zoledronic acid belongs to the bisphosphonate group of medicines. It binds strongly to bone and inhibits osteoclasts, the cells responsible for breaking down bone tissue. By slowing excessive bone resorption, it reduces the release of calcium from bone and helps control cancer-related hypercalcaemia. The same action helps reduce skeletal complications when cancer or multiple myeloma affects bone.
How it is taken
Xolnic is intended for administration by a healthcare professional as an intravenous infusion after appropriate preparation. Zoledronic acid 4 mg doses used for cancer-related indications must be infused over no less than 15 minutes. Kidney function should be assessed before treatment, and patients should be adequately hydrated when clinically appropriate. Concentrated formulations must be diluted with a compatible calcium-free infusion solution before administration. The exact preparation instructions for the Xolnic presentation should be checked on its current package insert before use.
Important warnings
Zoledronic acid can cause clinically important kidney injury, so renal function should be checked before treatment and monitored during therapy. Adequate hydration is important, while excessive hydration should be avoided in patients at risk of heart failure. Correct pre-existing hypocalcaemia and monitor calcium, phosphate and magnesium as clinically indicated. Osteonecrosis of the jaw has been reported; a dental assessment and appropriate preventive dental care should be considered before treatment, particularly when other risk factors are present. Avoid invasive dental procedures where possible during therapy and report persistent jaw pain, swelling, loose teeth or poor healing. Severe hypocalcaemia may cause muscle spasms, numbness, tingling or seizures and requires medical attention. Serious allergic reactions can occur. Zoledronic acid should not be given with another zoledronic-acid product or another bisphosphonate without specific medical direction. Use caution with nephrotoxic medicines and medicines that can further lower calcium, including aminoglycosides, calcitonin and loop diuretics.
Side effects and monitoring
Common effects can include fever, fatigue, nausea, vomiting, bone or joint pain, muscle aches, headache, anaemia, constipation and shortness of breath. An acute-phase reaction with fever, chills, fatigue and muscle, joint or bone pain can occur within the first few days after an infusion. Serious or less common problems include kidney impairment or renal failure, hypocalcaemia, severe allergic reactions, osteonecrosis of the jaw and atypical femoral fractures. Seek medical attention for markedly reduced urination, severe weakness or muscle spasms, breathing difficulty, facial swelling, persistent jaw symptoms, or new unexplained thigh or groin pain. Serum creatinine should be assessed before treatment doses, with calcium and other relevant electrolytes monitored when clinically indicated.
Pregnancy
Zoledronic acid should not be used during pregnancy. Animal studies have shown reproductive toxicity, and adequate human pregnancy data are not available. Women who could become pregnant should discuss appropriate pregnancy precautions with their healthcare professional.
Breastfeeding
Breastfeeding is contraindicated with zoledronic acid 4 mg concentrate formulations in authoritative product information. It is not known whether zoledronic acid passes into human milk.
Food and drink
There is no oral food-timing requirement because zoledronic acid is administered intravenously. Patients should be adequately hydrated before administration when clinically appropriate; hydration must be managed carefully in people at risk of heart failure.
Frequently asked questions
What should I expect after my first zoledronic acid infusion?
Some people develop an acute-phase reaction during the first few days, with symptoms such as fever, chills, fatigue and muscle, joint or bone aches. Tell your healthcare team if symptoms are severe, persistent or concerning.
Why does my dentist need to know that I receive zoledronic acid?
Zoledronic acid is associated with osteonecrosis of the jaw, a rare but serious problem involving damaged jawbone. Dental assessment and preventive care are recommended when appropriate, and your doctor and dentist should know about treatment before invasive dental procedures.
Do I need to drink extra water before a zoledronic acid infusion?
Adequate hydration is important before treatment when clinically appropriate, especially because zoledronic acid can affect kidney function. The healthcare team should determine hydration needs because excessive fluids may be unsuitable for some people, including those at risk of heart failure.
Why are kidney tests done before zoledronic acid treatment?
Zoledronic acid can impair kidney function, and the risk is greater in some patients with existing renal problems or other risk factors. Serum creatinine should therefore be assessed before treatment doses as directed by the prescribing information.
How long should a 4 mg zoledronic acid infusion take?
The infusion should be administered over no less than 15 minutes. Giving it too rapidly can increase the risk of kidney toxicity.
Can zoledronic acid cause low calcium?
Yes. Zoledronic acid can lower blood calcium, sometimes significantly. Calcium and related electrolytes may need monitoring, and symptoms such as muscle spasms, numbness, tingling or seizures require prompt medical assessment.
Can I have dental work while receiving zoledronic acid?
Tell both your dentist and treating doctor before having dental treatment. Because invasive dental procedures may increase the risk of osteonecrosis of the jaw, the healthcare professionals managing your treatment should decide how necessary procedures are handled.
Is Xolnic 4 Mg Injection a prescription medicine?
Yes. Zoledronic acid injection is a prescription medicine that requires administration and monitoring by appropriately trained healthcare professionals.
Sources
Medical information notice: This information does not replace advice from a qualified healthcare professional. Use prescription medicine only as directed by the prescriber and the approved product information.
| Active Ingredients | Zoledronic acid (4Mg) |
|---|---|
| Manufacturer | Khandelwal Laboratories Pvt Ltd |
| Packaging | Qty |
| strength | 4mg |
| Delivery Time | 6 To 15 days |
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