Cezol 4 Mg Injection (Zoledronic Acid)
Price range: $139.38 through $345.00Required
| Pack Size | Price | Unit Price | Quantity | |
|---|---|---|---|---|
| 2 Injection | $139.38 | $69.69 / injection | ||
| 4 Injection | $243.50 | $60.88 / injection | ||
| 6 Injection | $345.00 | $57.50 / injection |
About Cezol 4 Mg Injection (Zoledronic Acid)
Medicine information
- Active ingredient
- Zoledronic acid
- Indication
- Treatment of hypercalcemia of malignancy and treatment of patients with multiple myeloma or documented bone metastases from solid tumors, together with standard anticancer therapy.
- Manufacturer
- Health Biotech Limited
- Strength
- 4 mg
- Dosage form
- Lyophilized powder for injection
- Route
- Intravenous infusion
Medicine overview
Cezol 4 Mg Injection contains zoledronic acid, a bisphosphonate medicine that reduces excessive breakdown of bone. Health Biotech Limited lists zoledronic acid 4 mg as a lyophilized product for injection in its oncology range. Zoledronic acid 4 mg formulations are used for cancer-related high blood calcium and for reducing skeletal complications in patients with multiple myeloma or bone metastases from solid tumors. The medicine is administered by intravenous infusion under healthcare supervision.
What it is used for
Zoledronic acid 4 mg is used to treat hypercalcemia of malignancy, meaning significantly raised blood calcium caused by cancer. It is also indicated for patients with multiple myeloma and for documented bone metastases from solid tumors when used alongside standard anticancer treatment. In prostate cancer, the oncology prescribing information specifies use after progression following at least one hormonal therapy.
How it works
Zoledronic acid is a bisphosphonate that binds strongly to mineralized bone and inhibits osteoclasts, the cells responsible for breaking down bone tissue. By reducing osteoclast activity and bone resorption, it decreases the release of calcium from bone into the bloodstream. This action helps control cancer-related hypercalcemia and reduces the damaging effects of increased bone breakdown associated with multiple myeloma and metastatic bone disease.
How it is taken
Cezol is intended for intravenous administration by a healthcare professional and should not be self-administered. Health Biotech identifies its 4 mg zoledronic acid formulation as lyophilized powder for injection. For oncology zoledronic acid 4 mg products, prescribing information requires preparation for intravenous infusion and specifies that a single dose must be infused over at least 15 minutes. Kidney function and hydration status should be assessed as clinically appropriate before administration.
Important warnings
Do not use zoledronic acid in patients with hypersensitivity to zoledronic acid or its components. Kidney toxicity, including renal failure, can occur; serum creatinine should be checked before each oncology dose, and particular caution is required with renal impairment, dehydration, nephrotoxic medicines and diuretics. Correct hypocalcemia before treatment and monitor calcium and other relevant electrolytes. Osteonecrosis of the jaw has been reported, particularly in cancer patients receiving intravenous bisphosphonates; preventive dental assessment is recommended and invasive dental procedures should generally be avoided during treatment where possible. Severe bone, joint or muscle pain and atypical femoral fractures can occur. Patients should report persistent thigh or groin pain, jaw pain or swelling, loose teeth, non-healing mouth sores, symptoms of low calcium, or signs of a serious allergic reaction. Avoid concurrent treatment with other zoledronic-acid products or other bisphosphonates unless specifically directed by the treating clinician.
Side effects and monitoring
Common effects reported with oncology zoledronic acid include nausea, fatigue, anemia, bone pain, constipation, fever, vomiting and shortness of breath. Flu-like reactions, muscle or joint pain and electrolyte abnormalities can also occur. Serious risks include renal impairment or renal failure, severe hypocalcemia, osteonecrosis of the jaw, severe musculoskeletal pain, serious hypersensitivity reactions and atypical femoral fractures. Serum creatinine should be monitored before each oncology dose, with calcium and other electrolytes monitored when clinically indicated. Seek prompt medical attention for breathing or facial swelling, marked muscle spasms or tingling suggesting low calcium, substantially reduced urination, persistent jaw symptoms, or unexplained thigh or groin pain.
Pregnancy
Zoledronic acid can cause fetal harm based on its mechanism of action and animal data. Pregnancy status should be verified before treatment in patients who can become pregnant, and effective contraception is advised during and after treatment. Because bisphosphonates remain incorporated in bone and may be released for a prolonged period, pregnancy planning should be discussed with the treating clinician.
Breastfeeding
Breastfeeding is not advised during and after zoledronic acid treatment. It is not known whether zoledronic acid is present in human milk, but the medicine remains bound in bone for a prolonged period and serious adverse effects in a breastfed child cannot be excluded.
Food and drink
No product-specific food interaction was verified. Because Cezol is administered intravenously, administration does not depend on taking the medicine with a meal. Adequate hydration is important, particularly when zoledronic acid is being used for hypercalcemia of malignancy, but fluid management should follow the treating healthcare professional's instructions.
Frequently asked questions
What should I expect after a zoledronic acid infusion?
Flu-like symptoms such as fever, tiredness, bone or muscle pain, nausea and headache can occur after zoledronic acid. Contact your healthcare team if symptoms are severe, persistent or accompanied by signs of low calcium, kidney problems or an allergic reaction.
Do I need to see a dentist before receiving Cezol?
A dental examination is recommended before intravenous zoledronic acid treatment, particularly for patients with cancer and other risk factors for osteonecrosis of the jaw. Tell your doctor and dentist about planned extractions, implants or other invasive dental procedures.
Why are kidney tests needed before zoledronic acid?
Zoledronic acid can impair kidney function and, rarely, cause renal failure. Oncology prescribing information recommends checking serum creatinine before each dose and taking additional precautions in people with kidney impairment, dehydration or other renal risk factors.
Can zoledronic acid lower my calcium level?
Yes. Zoledronic acid can cause hypocalcemia, which means abnormally low blood calcium. Existing hypocalcemia should be corrected before treatment, and calcium, vitamin D and relevant laboratory monitoring may be required according to the treating clinician's instructions.
How long does a zoledronic acid infusion take?
Oncology prescribing information states that zoledronic acid doses should be administered by intravenous infusion over at least 15 minutes. The healthcare team prepares and administers the medicine; it should not be self-injected.
Can I have a tooth removed while receiving zoledronic acid?
Invasive dental procedures can increase concern about osteonecrosis of the jaw in patients receiving intravenous bisphosphonates. Tell both your treating clinician and dentist before an extraction or other invasive dental procedure so they can determine the appropriate approach.
Can Cezol be used during pregnancy?
Zoledronic acid can cause fetal harm and should not be used during pregnancy unless the treating specialist determines otherwise for the clinical situation. Pregnancy status should be checked before treatment when relevant, and effective contraception is advised during and after therapy.
Can Cezol be used while breastfeeding?
Breastfeeding is not advised during and after zoledronic acid treatment because serious adverse effects in a breastfed child cannot be excluded.
Does Cheap Generic Med ship Cezol internationally?
Cheap Generic Med serves multiple international destinations, including the United States, United Kingdom, Canada, Australia, Singapore, New Zealand, Japan and South Africa. Shipping availability does not establish that personal import of this prescription medicine is permitted; prescription and import requirements depend on the destination and individual circumstances.
Sources
Medical information notice: This information does not replace advice from a qualified healthcare professional. Use prescription medicine only as directed by the prescriber and the approved product information.
| Active Ingredients | Zoledronic acid (4Mg) |
|---|---|
| Manufacturer | Health Biotech Limited |
| Packaging | Qty |
| strength | 4mg |
| Delivery Time | 6 To 15 days |
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