Progynon Depot 10 Mg/ 1ml (Estradiol Valerate Injection)
Price range: $45.87 through $118.13Required
| Pack Size | Price | Unit Price | Quantity | |
|---|---|---|---|---|
| 10 Injection | $45.87 | $4.59 / injection | ||
| 30 Injection | $75.50 | $2.52 / injection | ||
| 60 Injection | $118.13 | $1.97 / injection |
About Progynon Depot 10 Mg/ 1ml (Estradiol Valerate Injection)
Medicine information
- Active ingredient
- Estradiol valerate
- Indication
- Estrogen replacement therapy for moderate to severe menopausal vasomotor symptoms; moderate to severe vulvar and vaginal atrophy associated with menopause; hypoestrogenism due to hypogonadism, castration, or primary ovarian failure. Estradiol valerate injection is also indicated for palliative treatment of advanced androgen-dependent prostate carcinoma in some approved labeling.
- Strength
- 10 mg/mL
- Dosage form
- Injection, solution
- Route
- Intramuscular
Medicine overview
Progynon Depot 10 mg/1 mL is an injectable estrogen product containing estradiol valerate, a long-acting ester of estradiol. The stated strength is equivalent to 10 mg of estradiol valerate in each 1 mL of injection. Estradiol is the main naturally occurring estrogen hormone. Intramuscular estradiol valerate preparations are used to replace estrogen when the body produces too little and for certain other estrogen-responsive conditions. The exact manufacturer and pack configuration of the specified Progynon Depot presentation could not be reliably verified from a current authoritative product source.
What it is used for
Estradiol valerate injection is used for estrogen replacement in conditions associated with estrogen deficiency. Verified indications for 10 mg/mL estradiol valerate injection include moderate to severe menopausal hot flushes and related vasomotor symptoms, moderate to severe vulvar and vaginal atrophy, and hypoestrogenism caused by hypogonadism, removal of the ovaries, or primary ovarian failure. Approved labeling also includes palliation of advanced androgen-dependent prostate cancer.
How it works
Estradiol valerate is converted in the body to estradiol. Estradiol binds to estrogen receptors and produces effects similar to the estrogen naturally made by the body. It helps maintain estrogen-responsive tissues, including the reproductive tract, breasts, bone, and other tissues. When estrogen production is reduced, replacing estrogen can lessen symptoms caused by estrogen deficiency. The valerate ester and oil-based intramuscular formulation allow the medicine to be released over a longer period than rapidly acting estradiol preparations.
How it is taken
Estradiol valerate injection is given by deep intramuscular injection. It should be administered using appropriate intramuscular injection technique and according to the regimen prescribed for the condition being treated. The required dose and interval vary by indication, so patients should not create or change an injection schedule themselves. Estrogen treatment should be periodically reviewed to determine whether continued treatment remains appropriate.
Important warnings
Do not use estradiol valerate in pregnancy or in patients with unexplained abnormal genital bleeding, known or suspected estrogen-dependent cancer, active or previous deep-vein thrombosis or pulmonary embolism, recent or active arterial thromboembolic disease such as stroke or myocardial infarction, significant liver dysfunction or disease, or hypersensitivity to the product's ingredients. Estrogen therapy can increase the risk of blood clots, stroke and other cardiovascular events. In patients with a uterus, estrogen without adequate progestogen exposure increases the risk of endometrial cancer. Breast and ovarian cancer risks require consideration during longer-term hormone therapy. Seek urgent medical attention for symptoms suggesting a blood clot, stroke, severe allergic reaction, sudden vision changes, chest pain, unusual severe headache, or unexplained persistent or recurrent vaginal bleeding. Medical history, treatment duration and the continuing need for estrogen should be reviewed periodically.
Side effects and monitoring
Commonly reported estrogen-related effects can include headache, breast pain or tenderness, nausea, abdominal discomfort, fluid retention and changes in vaginal bleeding. Less common but serious complications include venous thromboembolism, pulmonary embolism, stroke, myocardial infarction, gallbladder disease, severe allergic reactions and estrogen-dependent malignancies. Unexpected or persistent vaginal bleeding requires medical assessment. Patients receiving ongoing systemic estrogen may require periodic clinical review, including evaluation of blood pressure, breast and gynecological health and other risk factors according to individual circumstances.
Pregnancy
Estradiol valerate injection should not be used during pregnancy. There is no indication for estrogen replacement therapy during pregnancy. If pregnancy occurs during treatment, the prescribing healthcare professional should be contacted.
Breastfeeding
Estrogens can pass into human milk and may reduce the quantity and quality of breast milk. Estradiol valerate should therefore be used during breastfeeding only after appropriate medical assessment.
Storage
Store estradiol valerate injection at controlled room temperature, 20°C to 25°C (68°F to 77°F), and keep out of reach of children. Current U.S. labeling for a 10 mg/mL estradiol valerate injection also instructs users to protect the vial from light and keep it in its carton until use.
Frequently asked questions
How long does estradiol valerate stay active after an injection?
Estradiol valerate is formulated as a long-acting intramuscular estrogen, so its effects continue beyond the day of injection. The appropriate injection interval depends on the indication and prescribed regimen and should not be changed without medical guidance.
When should estradiol levels be checked if I use estradiol valerate injections?
Blood-test timing depends on why estradiol is being used and what the prescriber is trying to measure. Because hormone concentrations change after an injection, use the testing schedule specified by the clinician interpreting the results rather than choosing a testing time independently.
Can I use estradiol tablets as well as Progynon Depot injections?
Do not combine or change estrogen formulations unless your prescriber has specifically instructed you to do so. Using more than one systemic estrogen product can alter total estrogen exposure and may increase adverse-effect risks.
Does Progynon Depot have to be injected into a muscle?
Yes. Estradiol valerate injection of this type is intended for deep intramuscular administration. It should not be given by another route unless the specific product labeling explicitly permits it.
What symptoms need urgent medical attention while using estradiol valerate?
Obtain urgent medical care for chest pain, sudden shortness of breath, coughing up blood, sudden weakness or numbness, severe unusual headache, sudden vision changes, or signs of a severe allergic reaction. Persistent or recurrent unexplained vaginal bleeding also requires prompt medical assessment.
Why is unusual vaginal bleeding important during estrogen treatment?
Estrogen can stimulate the lining of the uterus. Persistent or recurrent unexplained bleeding needs medical evaluation because systemic estrogen, particularly when used without adequate progestogen in someone with a uterus, can increase the risk of endometrial hyperplasia and cancer.
Can Cheap Generic Med ship Progynon Depot internationally?
Cheap Generic Med serves multiple international destinations, but availability of this exact product and its destination-specific prescription or import requirements are NOT VERIFIED. Shipping availability should not be interpreted as confirmation that personal import is permitted in a particular country.
Will a Cheap Generic Med international order have tracking?
Under the standard fulfilment model, tracked international shipping is used and a tracking number should be provided after dispatch. Carrier systems may take 24–72 hours to begin showing movement.
Sources
Medical information notice: This information does not replace advice from a qualified healthcare professional. Use prescription medicine only as directed by the prescriber and the approved product information.
| Active Ingredients | Estradiol Valerate Injection |
|---|---|
| Manufacturer | German Remedies |
| Packaging | Qty |
| strength | 10mg/1ml |
| Delivery Time | 6 To 15 days |
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