Zolesto 4 Mg Injection (Zoledronic Acid)
Price range: $210.00 through $520.00Required
| Pack Size | Price | Unit Price | Quantity | |
|---|---|---|---|---|
| 2 Injection | $210.00 | $105.00 / injection | ||
| 4 Injection | $376.67 | $94.17 / injection | ||
| 6 Injection | $520.00 | $86.67 / injection |
About Zolesto 4 Mg Injection (Zoledronic Acid)
Medicine information
- Active ingredient
- Zoledronic acid
- Indication
- Treatment of hypercalcemia of malignancy and treatment of patients with multiple myeloma or documented bone metastases from solid tumors together with standard anticancer therapy. Zoledronic acid formulations are also used for osteoporosis and other bone disorders, but the exact approved indications depend on the specific formulation.
- Manufacturer
- Gland Pharma Limited
- Packaging
- 10 mL injection in a vial
- Strength
- 4 mg
- Dosage form
- Injection
- Route
- Intravenous infusion
Medicine overview
Zolesto 4 Mg Injection contains zoledronic acid, a medicine from the bisphosphonate class. Bisphosphonates reduce the breakdown of bone by cells called osteoclasts. Intravenous zoledronic acid is used for conditions involving excessive bone resorption, including high blood calcium caused by cancer and bone complications associated with multiple myeloma or cancers that have spread to bone. Zolesto is administered intravenously by a healthcare professional and should not be self-injected.
What it is used for
Zoledronic acid 4 mg intravenous treatment is used for hypercalcemia of malignancy, meaning abnormally high blood calcium caused by cancer. It is also used with standard anticancer treatment in patients with multiple myeloma or documented bone metastases from solid tumors. Zoledronic acid products are additionally used for osteoporosis, although indications and dosing differ between formulations and should not be assumed to be interchangeable.
How it works
Zoledronic acid is a bisphosphonate that binds strongly to mineralized bone. It inhibits osteoclasts, the cells responsible for breaking down and resorbing bone. Reducing this activity slows excessive bone loss and decreases the release of calcium from bone. This action helps control cancer-related high calcium levels and reduces skeletal complications associated with cancers involving bone.
How it is taken
Zolesto is given into a vein by a doctor, nurse, or other qualified healthcare professional; it should not be self-administered. For zoledronic acid 4 mg used for cancer-related indications, authoritative prescribing information specifies an intravenous infusion lasting at least 15 minutes. Kidney function and hydration status should be assessed as appropriate before treatment. The exact dose and treatment interval depend on the indication and renal function and must be determined by the treating clinician.
Important warnings
Do not use zoledronic acid in patients with hypersensitivity to zoledronic acid or components of the injection. Kidney injury, including renal failure, can occur; renal function should be assessed before treatment and serum creatinine monitored as indicated. Dehydration and other medicines that can harm the kidneys can increase renal risk. Hypocalcemia must be corrected, and calcium, phosphate and magnesium may require monitoring. Osteonecrosis of the jaw has been reported, particularly in cancer patients; dental assessment and preventive dental care are advised before treatment, and invasive dental procedures should be avoided where possible during therapy. Severe bone, joint or muscle pain and atypical femur fractures can occur. Seek medical attention for severe allergic symptoms, persistent jaw pain or non-healing oral lesions, new thigh or groin pain, or symptoms suggesting severe low calcium. Zoledronic acid products containing the same active ingredient should not be used concurrently.
Side effects and monitoring
Common adverse effects reported with zoledronic acid 4 mg in cancer-related treatment include nausea, fatigue, anemia, bone pain, constipation, fever, vomiting and shortness of breath. Serious or less common problems include kidney impairment or failure, hypocalcemia and other electrolyte disturbances, osteonecrosis of the jaw, severe musculoskeletal pain, atypical femur fractures, ocular inflammation and serious hypersensitivity reactions. Serum creatinine should be monitored, and calcium, phosphate and magnesium may also require assessment. Prompt medical attention is appropriate for breathing difficulty or swelling suggestive of an allergic reaction, severe or persistent jaw symptoms, new thigh or groin pain, significant muscle spasms or tingling, or severe eye pain or inflammation.
Pregnancy
Zoledronic acid can cause fetal harm based on its mechanism of action and animal data. Pregnancy status should be considered before treatment, and females of reproductive potential should be advised about effective contraception during and after treatment.
Breastfeeding
Breastfeeding is not advised during and after zoledronic acid treatment because of the potential for serious adverse reactions in a breastfed child. It is not known whether zoledronic acid is present in human milk.
Food and drink
No food-related administration requirement was verified for this intravenous product. Adequate hydration is important, particularly when zoledronic acid is used for hypercalcemia of malignancy, while excessive hydration should be avoided in patients in whom it could cause complications.
Frequently asked questions
What should I expect after my first zoledronic acid infusion?
Some patients develop fever, fatigue, aches or other flu-like symptoms after an infusion. Reactions vary between patients; contact your healthcare team if symptoms are severe, persistent or accompanied by signs of infection or another serious problem.
Do I need to be well hydrated before Zolesto?
Adequate hydration is important, particularly when zoledronic acid is being used for hypercalcemia of malignancy. Your healthcare team should assess hydration and kidney function and avoid excessive hydration when it could be unsafe.
Why does my dentist need to know that I receive zoledronic acid?
Zoledronic acid has been associated with osteonecrosis of the jaw. Dental examination and preventive dentistry are recommended before treatment in cancer patients, and invasive dental procedures should be avoided during treatment where possible.
Can I have a tooth extraction while receiving Zolesto?
Tell both your dentist and the clinician managing your zoledronic acid treatment before invasive dental work. Dental extraction is a recognized risk factor in reported cases of osteonecrosis of the jaw, so the treatment plan requires an individual clinical assessment.
How long does a zoledronic acid infusion take?
For the 4 mg cancer-related zoledronic acid regimen, prescribing information states that the intravenous infusion must last at least 15 minutes. The healthcare professional administering it determines the appropriate infusion procedure.
Why are kidney tests needed before zoledronic acid?
Zoledronic acid is eliminated mainly through the kidneys and can cause deterioration in renal function. Serum creatinine is therefore monitored, and kidney impairment, dehydration and other kidney-toxic medicines require particular attention.
Can Cheap Generic Med ship Zolesto internationally?
Cheap Generic Med serves multiple international destinations, but availability of this specific injectable product and its shipment requirements are NOT VERIFIED. Prescription and medicine-import requirements can also differ by destination.
Will an international Zolesto order clear customs?
Customs clearance cannot be guaranteed. Medicine shipments may be inspected, delayed, taxed or restricted, and prescription or personal-import requirements vary by destination and individual circumstances.
Sources
Medical information notice: This information does not replace advice from a qualified healthcare professional. Use prescription medicine only as directed by the prescriber and the approved product information.
| Active Ingredients | Zoledronic acid (4Mg) |
|---|---|
| Manufacturer | Gland Pharma Limited |
| Packaging | Qty |
| strength | 4mg |
| Delivery Time | 6 To 15 days |
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