Bonebay 60 Mg Tablet (Raloxifene)
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About Bonebay 60 Mg Tablet (Raloxifene)
Medicine information
- Active ingredient
- Raloxifene hydrochloride
- Indication
- Treatment and prevention of osteoporosis in postmenopausal women. Raloxifene is also used to reduce the risk of invasive breast cancer in certain postmenopausal women with osteoporosis or at high risk of invasive breast cancer. Bonebay 60 mg is specifically documented in India as a raloxifene 60 mg product for postmenopausal osteoporosis.
- Manufacturer
- Novartis India Ltd.
- Packaging
- 10 tablets in 1 strip.
- Strength
- 60 mg
- Dosage form
- Tablet
- Route
- Oral
Medicine overview
Bonebay 60 mg Tablet contains raloxifene, a selective estrogen receptor modulator (SERM). It is an oral medicine used mainly to prevent and treat osteoporosis after menopause. Raloxifene acts like estrogen in bone, helping reduce the loss of bone mineral density. It also blocks some estrogen effects in breast tissue and can reduce the risk of invasive breast cancer in certain postmenopausal women. Bonebay 60 mg is manufactured by Novartis India Ltd.
What it is used for
Bonebay 60 mg is used for the prevention and treatment of postmenopausal osteoporosis. By reducing bone loss, raloxifene lowers the risk of vertebral, or spinal, fractures. Raloxifene is also indicated to reduce the risk of invasive breast cancer in postmenopausal women with osteoporosis and in postmenopausal women considered at high risk for invasive breast cancer. It is not a treatment for existing breast cancer and is not indicated for preventing its recurrence.
How it works
Raloxifene is a selective estrogen receptor modulator. This means it can behave like estrogen in some tissues while blocking estrogen activity in others. In bone, it produces estrogen-like effects that reduce bone breakdown and help maintain bone mineral density after menopause. In breast tissue, it acts mainly as an estrogen antagonist, which helps explain its ability to reduce the risk of certain estrogen-sensitive invasive breast cancers in appropriate postmenopausal women.
How it is taken
Bonebay is taken by mouth. Verified raloxifene prescribing information specifies 60 mg once daily, and the tablet may be taken at any time of day with or without food. Take it consistently as prescribed. If calcium or vitamin D intake is inadequate, a healthcare professional may recommend supplementation. Prolonged immobility increases the risk of blood clots; raloxifene should be stopped at least 72 hours before and during prolonged immobilization according to prescribing guidance.
Important warnings
Do not use raloxifene with an active or previous venous thromboembolism, including deep-vein thrombosis, pulmonary embolism, or retinal-vein thrombosis. Raloxifene carries a serious warning for venous blood clots and an increased risk of death from stroke in postmenopausal women with coronary heart disease or increased risk of major coronary events. Prolonged immobility further increases clot risk. Seek urgent medical attention for unexplained leg swelling or pain, sudden chest pain, shortness of breath, coughing blood, or sudden vision changes. Use requires caution with stroke risk factors and liver or kidney impairment. Cholestyramine and similar anion-exchange resins should not be used concurrently; warfarin may require closer prothrombin-time monitoring. Concomitant systemic estrogen therapy is not recommended.
Side effects and monitoring
Common effects include hot flashes, leg cramps, peripheral swelling, flu-like symptoms, joint pain, and increased sweating. Serious effects are mainly venous thromboembolism, including deep-vein thrombosis and pulmonary embolism; sudden visual changes may indicate retinal-vein thrombosis. Urgent assessment is needed for leg pain or swelling, sudden chest pain, breathlessness, coughing blood, or sudden loss or blurring of vision. Patients taking warfarin may need closer prothrombin-time monitoring when raloxifene is started or stopped. Routine breast examinations and mammography remain necessary when raloxifene is being used to reduce breast-cancer risk.
Pregnancy
Raloxifene is contraindicated during pregnancy and is intended for postmenopausal women. Exposure during pregnancy may cause fetal harm.
Breastfeeding
Raloxifene should not be used by breastfeeding women. Its use is intended for postmenopausal women, and Indian formulary guidance lists lactation as a contraindication.
Food, drink and interactions
No specific direct alcohol interaction is established in the prescribing information reviewed. However, excessive alcohol intake can adversely affect bone health, so patients being treated for osteoporosis are advised to avoid drinking large amounts of alcohol.
Food and drink
Raloxifene can be taken with or without food. Adequate dietary calcium and vitamin D are important during osteoporosis treatment; supplementation may be recommended when dietary intake is insufficient.
Storage
Store protected from light and moisture at 20–25°C. Keep the medicine securely out of the reach of children.
Frequently asked questions
Does raloxifene actually improve bone density or just slow bone loss?
Raloxifene reduces bone loss and can increase bone mineral density in postmenopausal women. Its demonstrated fracture benefit is primarily a reduction in vertebral, or spinal, fractures.
Can Bonebay cause hot flashes or sweating?
Yes. Hot flashes and increased sweating are recognized side effects of raloxifene, and hot flashes are particularly common during the earlier months of treatment.
How serious is the blood-clot risk with raloxifene?
Blood clots are an important recognized risk. Raloxifene must not be used by women with a current or previous venous blood clot, and urgent medical attention is needed for symptoms such as unexplained leg swelling, sudden chest pain, breathlessness, or coughing blood.
What should I do if I will be sitting still for a long journey or having surgery?
Prolonged immobility can increase the risk of venous blood clots. Prescribing guidance calls for raloxifene to be stopped at least 72 hours before and during prolonged immobilization, with treatment restarted only when the patient is fully mobile; discuss planned surgery or prolonged immobility with the prescriber.
Can Bonebay 60 mg be taken with food?
Yes. Raloxifene 60 mg can be taken with or without food and at any time of day.
Does raloxifene prevent all types of breast cancer?
No. Raloxifene can reduce the risk of invasive breast cancer in certain postmenopausal women, but it does not eliminate breast-cancer risk, treat existing invasive breast cancer, prevent recurrence, or reduce the risk of noninvasive breast cancer.
Do I still need breast screening while taking raloxifene?
Yes. Regular breast examinations and mammograms should continue according to the screening plan recommended by your healthcare professional.
Is Bonebay 60 mg a prescription medicine?
Yes. Raloxifene hydrochloride is listed as a Schedule H medicine in India and is therefore a prescription medicine.
Sources
Medical information notice: This information does not replace advice from a qualified healthcare professional. Use prescription medicine only as directed by the prescriber and the approved product information.
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