Acivir IV Injection (Acyclovir)
Price range: $97.70 through $227.00Required
| Pack Size | Price | Unit Price | Quantity | |
|---|---|---|---|---|
| 3 Injection | $97.70 | $32.57 / injection | ||
| 6 Injection | $162.70 | $27.12 / injection | ||
| 9 Injection | $227.00 | $25.22 / injection |
About Acivir IV Injection (Acyclovir)
Medicine information
- Active ingredient
- Acyclovir
- Indication
- Treatment of serious herpesvirus infections, including mucocutaneous herpes simplex infections in immunocompromised patients, severe initial genital herpes, herpes simplex encephalitis, neonatal herpes simplex infection, and varicella-zoster infection in immunocompromised patients.
- Manufacturer
- Cipla Ltd
- Packaging
- 10 mL vial
- Strength
- 250 mg
- Dosage form
- Injection
- Route
- Intravenous infusion
Medicine overview
Acivir IV Injection contains acyclovir, an antiviral medicine active against herpes viruses. The 10 mL presentation contains acyclovir 25 mg/mL, equivalent to 250 mg in the vial. It is given by intravenous infusion and is used when treatment with injectable acyclovir is clinically appropriate, including for certain serious herpes simplex and varicella-zoster infections. Acyclovir limits viral replication rather than eliminating herpes viruses from the body.
What it is used for
Intravenous acyclovir is used for serious infections caused by susceptible herpes viruses. Established uses include mucosal and skin herpes simplex infections in immunocompromised patients, severe initial genital herpes, herpes simplex encephalitis, neonatal herpes simplex infection, and varicella-zoster infection in immunocompromised patients. The specific indication and treatment course depend on the infection, age, kidney function, and clinical circumstances.
How it works
Acyclovir is a synthetic purine nucleoside analogue. In cells infected with herpes simplex or varicella-zoster virus, viral thymidine kinase helps convert acyclovir into its active triphosphate form. This active form interferes with viral DNA polymerase and terminates the growing viral DNA chain. As a result, the virus has greater difficulty making new copies of its genetic material, which limits further viral replication.
How it is taken
Acivir IV Injection is administered into a vein by a healthcare professional and should not be self-injected. Intravenous acyclovir is given as a slow infusion; rapid or bolus intravenous injection must be avoided because it increases the risk of kidney injury. Adequate hydration is important during intravenous treatment. The prescribed amount and treatment duration depend on the infection and patient factors, and kidney impairment may require dosage adjustment.
Important warnings
Do not use acyclovir in patients with known hypersensitivity to acyclovir or valacyclovir. Intravenous treatment can cause acute kidney injury, particularly with rapid administration, dehydration, pre-existing kidney impairment, or concurrent nephrotoxic medicines; adequate hydration and appropriate renal assessment are important. Use caution with medicines that affect kidney function and with probenecid, which can reduce acyclovir renal clearance. Neurological reactions including confusion, hallucinations, tremor, agitation, seizures, encephalopathy, and coma have been reported, particularly in patients with renal impairment or older adults. Severe allergic reactions, serious skin reactions, renal failure, and TTP/HUS have also been reported. Accidental infusion outside the vein can cause severe local inflammation and tissue damage.
Side effects and monitoring
Commonly reported effects of intravenous acyclovir include inflammation or phlebitis at the infusion site, nausea, vomiting, and temporary increases in serum creatinine or blood urea nitrogen. Rash, itching, hives, and elevated liver enzymes may also occur. Serious or less common reactions include acute renal failure, severe allergic reactions, neurological changes such as confusion, hallucinations or seizures, severe skin reactions, blood-cell abnormalities, hepatitis, and severe tissue injury if the medicine leaks outside the vein. Kidney function and hydration status should be assessed as clinically appropriate. Seek prompt medical attention for markedly reduced urination, severe swelling, breathing difficulty, extensive rash, seizures, or significant changes in alertness or behaviour.
Pregnancy
Acyclovir should be used during pregnancy only when the expected benefit justifies the potential risk. Available pregnancy registry information has not shown a birth-defect rate above that of the general population, but the data are not sufficient to rule out uncommon risks.
Breastfeeding
Acyclovir passes into human breast milk. It should be used during breastfeeding with caution and only when clinically indicated; the treating healthcare professional should consider the need for therapy and the circumstances of the nursing infant.
Food, drink and interactions
No specific direct interaction between acyclovir and alcohol has been established. Because intravenous acyclovir is generally used for clinically significant infections and adequate hydration is important during treatment, alcohol use should be discussed with the treating healthcare professional.
Food and drink
Food does not affect an intravenously administered medicine. Adequate hydration is important during intravenous acyclovir treatment because dehydration can increase the risk of kidney injury. Follow the healthcare team's instructions regarding fluids if another medical condition requires fluid restriction.
Storage
Store below 25°C.
Frequently asked questions
Can IV acyclovir affect my kidneys?
Yes. Intravenous acyclovir can cause kidney injury, particularly with dehydration, kidney impairment, rapid administration, or other medicines that can harm the kidneys. Slow infusion, adequate hydration, and appropriate kidney-function monitoring help reduce this risk.
Why does Acivir IV have to be given slowly?
Slow intravenous infusion reduces the risk of acyclovir crystals forming in the kidney tubules and causing kidney damage. Rapid or bolus intravenous injection should be avoided.
Why might a doctor use IV acyclovir instead of tablets?
Intravenous acyclovir is used for certain serious herpesvirus infections or clinical situations in which injectable treatment is appropriate, including herpes encephalitis, neonatal herpes and some severe infections in immunocompromised patients.
Does IV acyclovir cure herpes permanently?
No. Acyclovir suppresses replication of susceptible herpes viruses and helps treat the active infection, but it does not remove latent herpes virus from the body.
Do my kidneys need monitoring while I receive Acivir IV?
Kidney function may need monitoring because acyclovir is mainly cleared through the kidneys and intravenous treatment can affect renal function. Monitoring is particularly important when kidney impairment, dehydration, older age, or other nephrotoxic medicines are present.
Can Acivir IV cause confusion or other neurological symptoms?
Yes, although these reactions are less common. Confusion, agitation, hallucinations, tremor, seizures and encephalopathy have been reported, with greater concern in people with impaired kidney function and in older adults.
Can I administer Acivir IV Injection myself at home?
It should be administered as an intravenous infusion under appropriate healthcare supervision. The infusion rate, hydration, kidney function and prescribed amount require clinical consideration.
Can Cheap Generic Med ship Acivir IV Injection internationally?
NOT VERIFIED
Sources
Medical information notice: This information does not replace advice from a qualified healthcare professional. Use prescription medicine only as directed by the prescriber and the approved product information.
| Active Ingredients | Acyclovir |
|---|---|
| Manufacturer | Cipla, India |
| Packaging | Qty |
| strength | 25mg |
| Delivery Time | 6 To 15 days |
Related products
Lamivir Hbv Tablet (Lamivudine)
Nevimune 200 Mg Tablet (Nevirapine)
Triomune 150 Mg/40 Mg/200 Mg Tablet (Stavudine)
Triomune 30+150+200 Mg (Stavudine)
XVir 0.5 Mg (Entecavir)
Zidovir 100 Mg (Zidovudine)
Reviews
There are no reviews yet.