Abamune L 600 Mg/300 Mg Tablet (Abacavir/Lamivudine)
Price range: $214.40 through $566.50Required
| Pack Size | Price | Unit Price | Quantity | |
|---|---|---|---|---|
| 30 Tablet/s | $214.40 | $7.15 / tablet | ||
| 60 Tablet/s | $391.40 | $6.52 / tablet | ||
| 90 Tablet/s | $566.50 | $6.29 / tablet |
About Abamune L 600 Mg/300 Mg Tablet (Abacavir/Lamivudine)
Medicine information
- Active ingredient
- Abacavir; Lamivudine
- Indication
- Treatment of HIV-1 infection in combination with other antiretroviral medicines.
- Manufacturer
- Cipla Ltd.
- Packaging
- Container of 30 tablets
- Strength
- 600/300 mg
- Dosage form
- Film-coated tablet
- Route
- Oral
Medicine overview
Abamune L 600 mg/300 mg Tablet is a fixed-dose antiretroviral medicine containing abacavir 600 mg and lamivudine 300 mg. Both active ingredients are nucleoside reverse transcriptase inhibitors (NRTIs), medicines that interfere with HIV replication. It is used with other antiretroviral medicines to treat HIV-1 infection. Abamune L is an oral tablet manufactured by Cipla Ltd. The medicine controls HIV infection but does not cure HIV.
What it is used for
Abamune L is used as part of combination antiretroviral therapy for HIV-1 infection. Abacavir and lamivudine reduce the ability of HIV to reproduce, helping lower the amount of virus in the body. Effective antiretroviral treatment supports immune function and reduces the risk of HIV-related illness. This fixed-dose tablet must be used with an appropriate HIV treatment regimen rather than as treatment on its own.
How it works
Abacavir and lamivudine are NRTIs. Inside cells, they are converted into active forms that compete with the natural building blocks HIV uses to make viral DNA. Their incorporation into viral DNA stops further DNA-chain formation and inhibits HIV reverse transcriptase, an enzyme needed for viral replication. This reduces the production of new HIV copies. The combination suppresses HIV but does not eliminate the virus from the body.
How it is taken
Take Abamune L by mouth as prescribed as part of a complete antiretroviral regimen. The abacavir 600 mg/lamivudine 300 mg fixed-dose combination can be taken with or without food. HLA-B*5701 screening should be performed before abacavir is started. Because the tablet contains fixed amounts of both medicines, it is not suitable when either component requires individual dose adjustment. If a dose is missed, take it when remembered unless otherwise instructed; do not double the next dose.
Important warnings
Abacavir can cause a serious and potentially fatal hypersensitivity reaction. HLA-B*5701-positive patients must not receive abacavir, and testing should be performed before treatment begins. Fever, rash, nausea, vomiting, diarrhea or abdominal pain, severe tiredness or aches, shortness of breath, cough, or sore throat can indicate hypersensitivity and require immediate medical assessment. If abacavir is stopped because hypersensitivity is suspected, it must never be restarted. Severe hepatitis B exacerbations can occur after lamivudine is discontinued in people with HIV/HBV coinfection, so liver function requires follow-up. Lactic acidosis and severe liver enlargement with fatty changes have been reported with nucleoside analogues. The fixed-dose combination is not recommended when renal function requires lamivudine dose adjustment and is contraindicated in moderate or severe hepatic impairment. Important interactions include methadone, sorbitol-containing medicines, and riociguat. Immune reconstitution inflammatory syndrome may occur after antiretroviral therapy begins.
Side effects and monitoring
Common reported effects include nausea, diarrhea, headache or migraine, dizziness, tiredness or weakness, trouble sleeping, depressed mood, and hypersensitivity reactions. Serious effects include potentially fatal abacavir hypersensitivity, lactic acidosis, severe liver problems, severe hepatitis B flares after stopping lamivudine in people with HBV/HIV coinfection, and severe allergic or skin reactions. Seek urgent medical attention for symptoms suggesting hypersensitivity, breathing difficulty, severe rash, marked weakness, or signs of liver injury such as jaundice. HIV viral load and other routine HIV treatment parameters should be monitored. HLA-B*5701 status must be established before starting abacavir; renal and liver function and hepatitis B status are also clinically relevant.
Pregnancy
Available pregnancy-registry data have not shown a higher overall rate of birth defects with abacavir or lamivudine than the reference background rate. Pregnancy should still be discussed with the clinician managing HIV treatment so that an appropriate antiretroviral regimen can be maintained. A pregnancy exposure registry is available for people exposed to antiretroviral medicines during pregnancy.
Breastfeeding
Abacavir and lamivudine are present in human milk. U.S. prescribing information instructs mothers with HIV-1 who are receiving abacavir/lamivudine not to breastfeed because of concerns including HIV transmission, development of viral resistance, and possible adverse effects in the infant. Breastfeeding recommendations for people with HIV can vary by country and clinical circumstances, so local specialist guidance should be followed.
Food, drink and interactions
Alcohol can reduce the elimination of abacavir and increase abacavir exposure. Clinical pharmacokinetic data found an increase in abacavir exposure with ethanol, although this was not considered clinically significant in the studied setting. Patients should discuss alcohol use with their HIV care provider, particularly if they have liver disease or other relevant medical conditions.
Food and drink
Abacavir/lamivudine tablets may be taken with or without food. When possible, avoid chronic use of sorbitol-containing medicines because sorbitol can reduce lamivudine exposure.
Storage
Store at 25°C (77°F); excursions between 15°C and 30°C (59°F to 86°F) are permitted under controlled room-temperature conditions. Keep out of reach of children.
Frequently asked questions
What happens if I miss a dose of Abamune L?
Take the missed dose when you remember it, but do not double the next dose or take more than prescribed. Consistent antiretroviral treatment is important for maintaining HIV suppression.
Why do I need an HLA-B*5701 test before taking Abamune L?
The test identifies a genetic variation strongly associated with serious abacavir hypersensitivity. People who test positive must not take abacavir-containing medicines.
Can I take Abamune L with food?
Yes. Abacavir/lamivudine tablets can be taken with or without food.
What symptoms of an abacavir allergic reaction should I watch for?
Seek medical advice immediately if symptoms consistent with hypersensitivity develop, particularly combinations of fever, rash, stomach symptoms, severe tiredness or aches, or respiratory symptoms. Suspected abacavir hypersensitivity requires urgent assessment, and abacavir must never be restarted after a hypersensitivity reaction.
Can I stop Abamune L when my HIV viral load becomes undetectable?
No treatment change should be made without your HIV care provider. Antiretroviral medicines control HIV rather than cure it, and stopping or skipping treatment can allow the virus to multiply again.
Why is hepatitis B important when taking abacavir/lamivudine?
Lamivudine is active against hepatitis B virus as well as HIV. In people with both HIV and hepatitis B, stopping lamivudine can cause a severe hepatitis B flare, so liver function should be monitored closely if treatment is discontinued.
Can I drink alcohol while taking Abamune L?
Alcohol can increase exposure to abacavir by slowing its elimination. The observed pharmacokinetic change was not considered clinically significant in the studied setting, but alcohol use should be discussed with your HIV care provider, especially if you have liver problems.
Does Cheap Generic Med ship Abamune L internationally?
Cheap Generic Med serves multiple international destinations, including the United States, United Kingdom, Canada, Australia, Singapore, New Zealand, Japan, and South Africa. Shipping availability does not guarantee that personal import is permitted; prescription and import requirements depend on the destination and individual circumstances.
Will my Abamune L order have tracking?
Under Cheap Generic Med's standard international fulfilment model, tracked shipping is used and a tracking number should be provided after dispatch. Carrier systems may take 24–72 hours to begin displaying movement.
Medical information notice: This information does not replace advice from a qualified healthcare professional. Use prescription medicine only as directed by the prescriber and the approved product information.
| Packaging | Qty |
|---|---|
| Delivery Time | 6 To 15 days |
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