5FU Cbc 500 Mg Injection (5-Fluorouracil)
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500 in stock
About 5FU Cbc 500 Mg Injection (5-Fluorouracil)
Medicine information
- Active ingredient
- Fluorouracil
- Indication
- Antineoplastic treatment of cancer. Intravenous fluorouracil is established for adenocarcinoma of the colon and rectum, breast, stomach and pancreas. The exact cancer type, combination regimen and treatment schedule are determined by the treating oncology team.
- Manufacturer
- Chandra Bhagat Pharma Private Limited
- Packaging
- 10 mL vial
- Strength
- 500 mg
- Dosage form
- Injection
- Route
- Intravenous
Medicine overview
5FU Cbc 500 Mg Injection is an anticancer medicine containing 500 mg of fluorouracil (5-FU). It belongs to the antimetabolite class of cytotoxic chemotherapy medicines, which interfere with processes cancer cells need to grow and divide. This product is supplied as an injection and is administered intravenously by trained healthcare professionals. Fluorouracil is used in established chemotherapy regimens for several cancers, particularly cancers of the colon and rectum, breast, stomach and pancreas.
What it is used for
Fluorouracil injection is used as part of chemotherapy for selected cancers. Established indications include adenocarcinoma of the colon and rectum, breast adenocarcinoma, gastric adenocarcinoma and pancreatic adenocarcinoma. Depending on the cancer and treatment protocol, fluorouracil may be used with other anticancer medicines. Treatment selection is made by an oncology specialist rather than based on the vial strength alone.
How it works
Fluorouracil is a nucleoside metabolic inhibitor, a type of antimetabolite chemotherapy. Inside cells it is converted into active metabolites that interfere with DNA production and, to a lesser extent, RNA formation. One important effect is inhibition of thymidylate synthase, an enzyme required to make DNA. These actions particularly affect rapidly dividing cells and can prevent cancer cells from continuing to grow, ultimately leading to cell death.
How it is taken
This medicine is administered into a vein by qualified healthcare professionals. Fluorouracil may be given as an intravenous bolus or intravenous infusion, depending on the prescribed chemotherapy regimen. Infusion regimens may be administered through a central venous line using an infusion pump. The dose and schedule depend on the cancer, treatment regimen, other medicines being given and the patient's clinical condition. Patients should not self-administer this cytotoxic injection.
Important warnings
Fluorouracil can cause severe or fatal toxicity in people with complete dihydropyrimidine dehydrogenase (DPD) deficiency; current prescribing information recommends DPYD genetic testing before treatment unless therapy must begin immediately. Important toxicities include severe diarrhea, mouth and gastrointestinal inflammation, bone-marrow suppression, hand-foot syndrome, neurologic toxicity, hyperammonemic encephalopathy and serious cardiac effects such as angina, myocardial ischemia, arrhythmias and heart failure. Warfarin used with fluorouracil can significantly increase INR and requires close monitoring. Patients should urgently report severe diarrhea or mouth sores, fever or signs of infection, unusual bleeding, chest pain, marked confusion, loss of coordination or other severe or unusually early symptoms.
Side effects and monitoring
Common or clinically important effects include nausea, vomiting, diarrhea, mouth inflammation or sores, reduced blood-cell counts and hand-foot syndrome, which can cause redness, pain or peeling of the palms and soles. Serious effects include severe myelosuppression, infection, severe gastrointestinal toxicity, cardiotoxicity, neurologic toxicity, hyperammonemic encephalopathy and severe reactions associated with DPD deficiency. Complete blood counts are required before treatment cycles and at appropriate intervals during therapy because neutropenia, thrombocytopenia and anemia can occur. Seek prompt medical attention for fever, severe diarrhea, severe mouth sores, unusual bleeding, chest pain, confusion or other rapidly worsening symptoms.
Pregnancy
Fluorouracil can cause fetal harm. It should generally be avoided during pregnancy unless the treating specialist determines that treatment is clinically necessary after considering the potential risks and benefits. Patients who are pregnant, could become pregnant or become pregnant during treatment should inform their oncology team promptly. Effective contraception is required during treatment and for an appropriate period afterward according to the applicable prescribing information.
Breastfeeding
Breastfeeding should be discontinued during systemic fluorouracil treatment because of the potential for serious adverse effects in a nursing infant.
Food and drink
No product-specific food or drink restrictions for 5FU Cbc 500 Mg Injection were reliably verified. Because this medicine is administered intravenously, food does not control its absorption in the way it can with an oral medicine. Follow the oncology team's instructions about eating and drinking during treatment.
Storage
Store below 25°C, protect from light, and do not refrigerate or freeze. Keep the container protected in its outer packaging. Fluorouracil is a cytotoxic medicine and requires appropriate handling and disposal by healthcare professionals.
Frequently asked questions
Will I always need a pump when receiving 5-FU?
No. Fluorouracil can be given as an intravenous bolus or infusion, and some infusion regimens use a central venous line and pump. The method depends on the chemotherapy regimen prescribed for you.
Can 5-FU cause mouth sores and diarrhea?
Yes. Mucositis, including mouth sores, and diarrhea are recognized fluorouracil toxicities. Contact your oncology team promptly if either becomes severe because treatment-related dehydration, infection and other complications may require medical care.
Why are blood counts checked during fluorouracil treatment?
Fluorouracil can suppress bone marrow and reduce white blood cells, platelets and red blood cells. Blood counts are therefore monitored before treatment cycles and at appropriate intervals during therapy.
What is DPD deficiency, and why does it matter with 5-FU?
DPD is an enzyme involved in breaking down fluorouracil. Complete or markedly reduced DPD activity can cause unusually severe or even fatal fluorouracil toxicity, so current prescribing information recommends assessment for relevant DPYD genetic variants before treatment unless immediate therapy is necessary.
Can 5-FU cause hand-foot syndrome?
Yes. Fluorouracil can cause hand-foot syndrome, with symptoms such as redness, pain, swelling, tenderness or peeling of the palms and soles. Tell your oncology team if these symptoms develop.
When should I urgently contact my medical team during 5-FU treatment?
Seek prompt medical advice for fever or signs of infection, severe diarrhea or mouth sores, unusual bleeding, chest pain, severe weakness, confusion, loss of coordination or other unusually severe or rapidly developing symptoms.
Can 5FU Cbc 500 Mg Injection be self-injected at home?
No. This cytotoxic medicine is intended for intravenous administration by trained healthcare professionals according to a prescribed chemotherapy regimen.
Will I need monitoring while receiving fluorouracil?
Yes. Blood counts are routinely monitored because fluorouracil can cause serious bone-marrow suppression. Additional clinical or laboratory monitoring may be required according to your chemotherapy regimen and other medicines.
Can Cheap Generic Med ship 5FU Cbc 500 Mg Injection internationally?
NOT VERIFIED
Sources
Medical information notice: This information does not replace advice from a qualified healthcare professional. Use prescription medicine only as directed by the prescriber and the approved product information.
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