Semi Daonil 2.5 Mg

Dr. Emily Brown

Dr. Ryan Mitchell

SKU

CMS618

USA Brand Name

DiaBeta

Strength

2.5mg

Generic Name

Glibenclamide

Manufacturer

Emcure Pharmaceuticals Ltd

## About Semi-Daonil

Semi-Daonil is a drug having Glibenclamide as an active ingredient. It is a hypoglycaemic agent indicated in the treatment of non-insulin dependent diabetes in patients who respond inadequately to dietary measures alone.

## USA Brands Equivalent To Semi-Daonil

Glyburide is the drug having the same salt, Glibenclamide as in Semi-Daonil, available in the United States market.

## Uses of Glibenclamide, The Salt Present In Semi-Daonil

Semi- Daonil is a Sulphonylurea, oral hypoglycaemic used to treat type 2 diabetes mellitus. It is used to control blood sugar level in people suffering from type 2 Diabetes. This drug is prescribed when the patient is not overweight and cannot tolerate metformin.

## How Semi-Daonil Works?

Semi-Daonil works by stimulating the Beta cells in the pancreas that produce insulin. It causes the beta cells to produce more insulin. This helps to decrease the amount of sugar in the blood of people with type 2 diabetes

## Manufacturer Of Semi-Daonil

Semi-Daonil is manufactured by Emcure Pharmaceuticals Ltd. and is available at all the leading online pharmacies, drugstores and medical supply stores.

## Dosage

Semi-Daonil must be taken as your doctor tells you. The usual starting dose is 5 mg daily. It is prescribed as a single dose to be taken with or immediately after breakfast.

## How To Take Semi-Daonil?

It can be taken with or just after first meal of the day, breakfast and can be taken with a glass of water. Also take care of diet & exercise with the drug

## Side Effects Of Semi-Daonil

It may cause certain side effects like-

Low Blood Sugar

Nausea

Allergic Reaction With A Rash Involving The Skin

Internal Lining Of The Skin

Metallic Taste

Heartburn

## How Long Should I Continue Taking Semi-Daonil?

Semi-Daonil must be taken as your doctor tells you. The usual starting dose is 5 mg daily take the advice of doctor before taking the medicine as its doses varies from patient to patient.

## Overdose Of Semi-Daonil

Don’t take more than the prescribed dose. If you have taken more than the prescribed dose, do consult your doctor immediately. The common symptoms of overdose side effects are Hypoglycemia.

## Missed Dose Of Semi-Daonil?

A missed dose should be taken as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and go back to your regular schedule.  Do not take multiple doses at the same time

## Drugs The Interact With Semi-Daonil

The following drugs are known to interact with Semi-Daonil

Bosentan: There is the potential for an increased risk of hepatotoxicity when glibenclamide is given with bosentan and therefore concomitant use should be avoided.

Analgesics and anti-inflammatory agents: Large doses of salicylates and possibly other NSAIDs may lower blood glucose levels and the glibenclamide dose may need to be reduced.

Antibacterials : Isoniazid may increase blood sugar levels, so the dose of sulphonylurea may need to be adjusted. Chloramphenicol, ciprofloxacin, co-trimoxazole, sulphonamides and tetracyclines may enhance the hypoglycaemic effect of glibenclamide. Concomitant use with rifamycins may reduce the hypoglycaemic effect of sulphonylureas.

Cytotoxic drugs : Crisantaspase may induce hyperglycaemia and the dose of glibenclamide may need to be adjusted.

Alcohol : May enhance the hypoglycaemic effect of glibenclamide.

Anticoagulants : Anticoagulants and disopyramide may enhance the hypoglycaemic effect of glibenclamide.

Antidepressants : Tricyclic antidepressants and MAOIs may enhance the hypoglycaemic effect of glibenclamide.

Antifungals : Miconazole increases plasma concentrations of sulfonylureas. There is the potential for fluconazole to increase the plasma concentration of glibenclamide.

Anti-gout agents: Enhanced hypoglycaemic effect with allopurinol, sulfinpyrazone and probenecid.

Antihypertensives : ACE inhibitors, such as captopril and enalapril, may enhance the hypoglycaemic effect of glibenclamide. Beta blockers may increase the hypoglycaemic effects of sulphonylureas and mask the symptoms of hypoglycaemia. Concomitant use with diazoxide may reduce the hypoglycaemic effect of sulphonylureas.

Antimalarials : Possible increase in hypoglycaemia with quinine and quinidine.

Antipsychotics : Chlorpromazine in daily doses of 100mg or more can reduce the hypoglycaemic effect of sulphonylureas.

Antiulcer drugs : Cimetidine and ranitidine may enhance the hypoglycaemic effect of glibenclamide.

## When Not To Take Semi-Daonil?

Semi- Daonil is contraindicated in following situations-

Patients known to have sensitivity to other sulfonylureas and related drugs

Juvenile onset diabetes

Diabetic ketoacidosis

Severe infection, stress, trauma, surgical procedures or other severe conditions where the drug is unlikely to control the hyperglycaemia.

Severe impairment of renal function

Hepatic impairment

Diabetic coma and precoma

Porphyria

Pregnancy

Elderly (> 70 years)

## General Information About Semi-Daonil

Semi- Daonil is a type of drug called a sulphonylurea. It is used to help control blood sugar levels in people with type 2 diabetes. This medicine must be taken in combination with diet, exercise and weight loss regime.  It has to be administered under consultation of Medical practitioner.

Semi-Daonil is a drug having Glibenclamide as an active ingredient. It is a hypoglycaemic agent indicated in the treatment of non-insulin dependent diabetes in patients who respond inadequately to dietary measures alone.