Pemeta 100 Solution for infusion

Dr. Emily Brown

Dr. Ryan Mitchell

SKU

CMS4343

USA Brand Name

Alimta

Strength

100Mg

Generic Name

Pemetrexed

Manufacturer

Cipla Ltd

## Pemeta 100 Solution For Infusion (Pemetrexed)

## What Is The Generic Name For Pemeta 100 Solution:

Pemetrexed is the generic version for Pemeta 100 Solution

## Which USA Brand is Equivalent To Pemeta 100 Solution (Pemetrexed):

Alimta

## About Pemeta 100 Solution (Pemetrexed)

Pemeta 100 Solution contains an active ingredient, Pemetrexed, which is used in the treatment of non-small cell lung cancer & malignant pleural mesothelioma. Non-small-cell lung cancer (NSCLC) is epithelial lung cancer apart from small cell lung carcinoma (SCLC). NSCLCs are relatively not sensitive to chemotherapy as compared to small cell carcinoma. Pleural mesothelioma is a uncommon malignant cancer which is caused by inhaling asbestos fibres into the lungs. Pleural mesothelioma is a type of cancer which develops in the cells that form the outer lining of the lungs & inner lining of the chest cavities. It is the most widespread cancer related to asbestos. This medicine is easily available at all the leading pharmacy, drugstores, & medical supply stores and must be taken strictly on doctor’s prescription only.

## Manufacturer :

Cipla Ltd. is one of the top pharmaceutical companies which manufacture Pemeta 100 Solution.

## Strength :

Pemeta 100 Solution contains an active constituent, Pemetrexed (100 mg). This medicine is easily obtainable in other substitutes also at all the leading online pharmacy, drugstores, & medical supply stores.

## What Are The Uses Of The Pemeta 100 Solution (Pemetrexed):

Pemeta 100 Solution is used in the treatment in the following conditions:

Malignant Pleural Mesothelioma

Non-Small Cell Lung Cancer

## How Pemeta 100 Solution (Pemetrexed) Works:

Pemeta 100 Solution has an active ingredient; Pemetrexed which is an anti-cancer medication . Pemetrexed is an antifolate which contains the pyrrolopyrimidine-based nucleus. Its antineoplastic action is implemented by disrupting folate dependent metabolic processes which is necessary for cell replication. Pemetrexed inhibits folate-dependent enzymes involved in the de novo biosynthesis of thymidine & purine nucleotides. Pemetrexed is transferred into cells by both the reduced folate carrier & membrane folate binding protein transport systems. Once in the cell, pemetrexed is transformed to polyglutamate forms by the enzyme folylpolyglutamate synthetase. The polyglutamate forms are retained in cells & are inhibitors of TS and GARFT. Polyglutamation is a time- & concentration-dependent process which occurs in tumor cells and, to a lesser extent, in normal tissues. Polyglutamated metabolites have an increased intracellular half-life ensuing in prolonged drug action in malignant cells.

## Before You Use Pemeta 100 Solution (Pemetrexed):

Make certain that:

You are not sensitive to Pemetrexed

You are not having any critical Disease

Your doctor must be well-informed about your medicinal history like your pre-existing disease, surgeries & Medications, Supplements, Food Habits, lifestyle, etc.

## What Should You Avoid While Taking Pemeta 100 Solution (Pemetrexed):

You should avoid taking alcohol

You should avoid driving

You should avoid taking Medicines without prescriptions

## When Not To Use Pemeta 100 Solution (Pemetrexed):

You should not take Pemeta 100 Solution if you:

Have ever noticed any Allergy/Hypersensitivity

Have liver problems

Have kidney problems

Have skin disorders

Have low blood cell count

Are pregnant

Have infections

Are breastfeeding

## Tell Your Doctor If You:

Have Allergy to the Infusion

Are taking Alcohol or Other Drugs

Have Liver disease

Have infections

## Dosage :

Pemeta 100 Solution contains an active ingredient, Pemetrexed, which is used in the treatment of non-small cell lung cancer & malignant pleural mesothelioma. This medicine is obtainable in different substitutes & strengths & has got to be purchased or taken on doctor’s prescription only. You must talk about with your physician for adjustment of dosage & time of the medicine since age & severity of the disease differ from person to person, and this can only be finest judged by your doctor.

Adults are advised to take Pemeta 100 Solution at a fixed time with or without food as instructed by your Doctor. You must take Pemeta 100 Solution regularly on time for better results.

## How Much Of The Pemeta 100 Solution (Pemetrexed) to Be Used:

As Pemeta 100 Solution is available in various strengths & substitutes, Patients are always advised to follow their doctor’s prescriptions & instructions to take Pemeta 100 Solution. You should not take the Infusion on your own & for a longer period than recommended by the doctor.

## How To Take The Pemeta 100 Solution (Pemetrexed):

Pemeta 100 Solution should be taken at a fixed time as directed by your doctor. Your doctor or nurse will give you Pemeta 100 Solution. Kindly do not self administer this medicine.

## For How Long Should You Continue Using Pemeta 100 Solution (Pemetrexed):

You are always advised to take Pemeta 100 Solution as prescribed. Do not start/stop using this medication on your own. You have to strictly follow all the directions given by your doctor. You should not take the Infusion in larger or smaller extent or for a longer period than suggested by your doctor.

## Overdose :

You have to seek medical emergency treatment and/ or make contact with your medical doctor instantly in case of any overdose symptoms. As Pemeta 100 Solution is administered in the hospital or clinical set by an experienced healthcare expert, the likelihood of an overdose is very low. However, emergency action will be initiated without delay by your medical doctor if they detect overdose symptoms.

## Missed Dose:

The missed dosage of the Infusion ought to be administered as quickly as possible. You should strictly skip the missed dosage if it is by now the time for your next planned dosage. It is advised not to double the dosage of the treatment to make up for the missed dosage. As Pemeta 100 Solution is administered in the hospital or clinical set by an experienced healthcare expert, the likelihood of a missed dose is very low.

## What Are The Side Effects Of The Pemeta 100 Solution (Pemetrexed):

Low WBC and Platelet count

Fever and chills

Mouth ulcers

Nausea and Vomiting

Skin rash

Decreased urine output

Blood in urine and stools

Diarrhea

Cough

Hair loss

Change in mood

Pharyngitis

Loss of appetite

Fatigue

Anemia (low number of red blood cells)

Neuropathy

## What Are The Common Drug Interactions:

Some medicines have been reported to interact with Pemeta 100 Solution. These interactions might generate some needless or unfavorable effects and/or cause your drug not to operate properly. You must constantly have a discussion with your doctor if you are taking other prescription/ Supplements so that well premeditated medication can be given. It interacts with the following medicines:

Clozapine

Live attenuated vaccines and related products

Fluoroquinolone antibiotic

It can also interact with the following disease condition:

Infections

Kidney disease

## Warning And Precaution:

Pemeta 100 Solution can worsen the conditions like:

Allergy

Kidney/ Liver disease

You have to use a consistent contraceptive method to avoid pregnancy while you are on this medication as it can cause birth defects

You have to regularly get your blood tests done to examine your blood cells, liver & kidney function, & electrolyte levels during treatment with this medicine

You must also get your blood pressure and levels of proteins in urine checked regularly while taking this medicine

You should not obtain this medicine if you are pregnant, planning to conceive or breastfeeding

You must not drive or operate heavy machines at the same time as taking this medicine as it may cause dizziness

Always talk about with your medical doctor straight away to get the most excellent possible treatment if you are observing several of the above mentioned conditions.

## Things To Remember:

Keep the Pemeta 100 Solution out of reach & sight of the children

This medicine is strictly used with vigilance for treatment of children

Pemeta 100 Solution is not suggested for use in pregnant women owing to the increased risk of harmful effects on the unborn baby

You must always check up the information in particular printed on the leaflet/ insert of the medicine

Always talk about with your medical doctor if you have any doubt in case of the dosage, time & strength of the medicine.

## Indications :

Pemeta 100 Solution should be taken as recommended by your doctor. Do not take this prescription for a longer period than recommended by the medical doctor.

## Storage :

Store the Pemeta 100 Solution at room temperature in dark & dry place. Make sure the Infusion is intact & not broken while purchasing or storing.