Pulmosil 10 Mg Injection 12.5 ml (Sildenafil Citrate)
Price range: $198.30 through $525.00Required
| Pack Size | Price | Unit Price | Quantity | |
|---|---|---|---|---|
| 3 Injection | $198.30 | $66.10 / injection | ||
| 6 Injection | $363.30 | $60.55 / injection | ||
| 9 Injection | $525.00 | $58.33 / injection |
About Pulmosil 10 Mg Injection 12.5 ml (Sildenafil Citrate)
Medicine information
- Active ingredient
- Sildenafil citrate
- Indication
- Pulmonary arterial hypertension (PAH), WHO Group I
- Manufacturer
- Sun Pharmaceutical Industries Ltd
- Strength
- 10 mg
- Dosage form
- Injection solution
- Route
- Intravenous
Medicine overview
Pulmosil 10 mg Injection 12.5 mL contains sildenafil, supplied as sildenafil citrate, at a concentration of 0.8 mg/mL, giving 10 mg of sildenafil in 12.5 mL. It is an intravenous phosphodiesterase type 5 (PDE5) inhibitor used in the management of pulmonary arterial hypertension (PAH). Sildenafil relaxes blood vessels in the lungs, helping reduce pulmonary vascular resistance and improve blood flow. Pulmosil is manufactured by Sun Pharmaceutical Industries Ltd.
What it is used for
Sildenafil injection is used to treat pulmonary arterial hypertension (PAH), a condition in which pressure is abnormally high in the blood vessels supplying the lungs. In adults with WHO Group I PAH, sildenafil therapy can improve exercise ability and delay clinical worsening. Injectable sildenafil is particularly relevant when intravenous treatment is required rather than oral administration.
How it works
Sildenafil blocks phosphodiesterase type 5 (PDE5), an enzyme involved in breaking down cyclic guanosine monophosphate (cGMP). Increased cGMP allows smooth muscle in the pulmonary blood vessels to relax. This vasodilation widens the vessels supplying the lungs and reduces pulmonary vascular resistance. The resulting reduction in pressure against which the right side of the heart pumps helps sildenafil improve blood flow through the pulmonary circulation.
How it is taken
Pulmosil is administered intravenously and should be given by a healthcare professional; it should not be self-administered. Authoritative sildenafil injection labeling describes administration as an intravenous bolus injection. The verified reference formulation contains 10 mg sildenafil in 12.5 mL (0.8 mg/mL). Treatment and dosing should follow the prescriber's instructions and the product-specific prescribing information.
Important warnings
Do not use sildenafil with organic nitrates because the combination can cause a dangerous fall in blood pressure. Concomitant use with riociguat is also contraindicated. Sildenafil can lower blood pressure, so particular caution is required in people with hypotension or receiving blood-pressure-lowering medicines. Strong CYP3A inhibitors are not recommended with sildenafil, and other PDE5 inhibitors should be avoided. Sildenafil is not recommended in pulmonary veno-occlusive disease because pulmonary edema may occur. Seek prompt medical attention for sudden loss or reduction of vision or hearing, or a prolonged erection. Sildenafil has also been associated with increased vaso-occlusive crises in patients with pulmonary hypertension secondary to sickle cell disease.
Side effects and monitoring
Common adverse effects reported with sildenafil treatment for PAH include headache, flushing, indigestion, diarrhea, back pain, muscle pain and pain in the limbs. Adverse events reported with sildenafil injection are similar to those seen with oral sildenafil. Serious concerns include significant hypotension, sudden vision loss, sudden hearing loss, priapism and hypersensitivity reactions. Patients should receive medical attention promptly for sudden visual or hearing changes, fainting or marked symptoms of low blood pressure, severe allergic symptoms, or an erection that persists abnormally. Blood pressure and the patient's clinical response to PAH treatment should be assessed as appropriate.
Pregnancy
Limited human data have not identified a clear association between sildenafil use during pregnancy and major birth defects, miscarriage, or adverse maternal or fetal outcomes. However, pulmonary arterial hypertension itself carries substantial risks during pregnancy. Use during pregnancy requires specialist assessment of the potential benefits and risks.
Breastfeeding
Sildenafil and its active metabolite have been reported in human breast milk, but available data are too limited to determine the risk to a breastfed infant. There is also insufficient information about effects on milk production. Breastfeeding during sildenafil treatment should therefore be discussed with the treating healthcare professional.
Food, drink and interactions
Sildenafil 50 mg did not increase the blood-pressure-lowering effect of alcohol in a study of healthy volunteers at a mean maximum blood alcohol level of 0.08%. However, this evidence does not specifically establish the safety of alcohol with Pulmosil intravenous treatment for PAH. Patients should ask their treating clinician about alcohol use in the context of their condition and other medicines.
Food and drink
Because Pulmosil is administered intravenously, food does not affect absorption through the gastrointestinal tract.
Frequently asked questions
Why does sildenafil help pulmonary arterial hypertension?
Sildenafil relaxes blood vessels in the lungs by inhibiting PDE5 and increasing cGMP activity. This lowers pulmonary vascular resistance and can improve exercise ability in PAH.
Can sildenafil for PAH make me feel dizzy?
Yes. Sildenafil can lower blood pressure, and dizziness may occur. Tell your healthcare team if dizziness is persistent or troublesome, and seek prompt medical care for fainting or severe symptoms of low blood pressure.
Is Pulmosil injection the same type of sildenafil used for erectile dysfunction?
The active medicine is sildenafil, but Pulmosil injection is an intravenous formulation used for pulmonary arterial hypertension. Sildenafil products for different indications, strengths and routes should not be treated as interchangeable.
Can Pulmosil Injection be given at home by myself?
It should not be self-administered. Intravenous sildenafil should be administered under appropriate healthcare supervision according to the prescribed treatment plan.
Can I use nitrate medicines while receiving sildenafil injection?
No. Organic nitrates are contraindicated with sildenafil because the combination can cause a potentially dangerous fall in blood pressure.
What should I do if I suddenly notice changes in my vision or hearing?
Seek prompt medical attention. Sudden decrease or loss of vision or hearing is an important warning associated with sildenafil and requires medical assessment.
Can Cheap Generic Med ship Pulmosil to the United States?
Cheap Generic Med serves the United States under its international shipping model. Delivery is typically estimated at 10–14 business days after dispatch, but customs or carrier delays can extend transit, and prescription and import requirements may apply.
Will my Pulmosil order have tracking?
Tracked international shipping is used under the standard Cheap Generic Med fulfilment model. A tracking number should be provided after dispatch, although it may take 24–72 hours for movement to appear in the carrier system.
Sources
Medical information notice: This information does not replace advice from a qualified healthcare professional. Use prescription medicine only as directed by the prescriber and the approved product information.
| Active Ingredients | Sildenafil Citrate |
|---|---|
| Manufacturer | Sun Pharmaceutical |
| Packaging | Qty |
| strength | 10mg |
| Delivery Time | 6 To 15 days |
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